ReviewNanomaterials (Basel, Switzerland)2022
Experimental and Computational Nanotoxicology-Complementary Approaches for Nanomaterial Hazard Assessment.
Review in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Toxicity of nanostructures in drug delivery applications.Pharmaceutical science advances · 2026Review
- Bridging Nano-Interface Interactions and Organ-Specific Toxicity: A Review of Machine Learning for Nanomaterials Risk Assessment.Molecules (Basel, Switzerland) · 2026Review
- New Perspective on Functionalized Metal Nanoparticles and Two-Dimensional Nanomaterials-Based Composites for Electrochemical Biomarker Sensing and Energy Storage Devices.Chemical record (New York, N.Y.) · 2026Review
- Predictive and Mechanism-Based Toxicity Evaluation of Engineered Nanoparticles.Nanomaterials (Basel, Switzerland) · 2026Article
- Exploring the Androgen Receptor Binding Affinity of Azole Derivatives through Multiscale Computational and Experimental Approaches.Environmental science & technology · 2025Article
- The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals.ACS pharmacology & translational science · 2025Review
- Review
- Food contaminants: mechanisms of toxicity, computational assessment, and mitigation.Frontiers in toxicology · 2025Review
- Review
- Green carbon dots in the era of AI: sustainable synthesis, intelligent drug delivery, advanced diagnostics, and bioimaging.Turkish journal of biology = Turk biyoloji dergisi · 2025Review
- In silico assessment of nanoparticle toxicity powered by the Enalos Cloud Platform: Integrating automated machine learning and synthetic data for enhanced nanosafety evaluation.Computational and structural biotechnology journal · 2024Article
- Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives.Molecules (Basel, Switzerland) · 2024Review
- The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential.Beilstein journal of nanotechnology · 2024Article
- Assessing the Cytotoxicity of TiOBiological trace element research · 2023Article
- Data-Driven Quantitative Intrinsic Hazard Criteria for Nanoproduct Development in a Safe-by-Design Paradigm: A Case Study of Silver Nanoforms.ACS applied nano materials · 2023Article
- Considerations on dosimetry for in vitro assessment of e-cigarette toxicity.Respiratory research · 2022Review
- ZnO/CeOJournal of functional biomaterials · 2022Article
- Article
- Analysis of Nanomaterials on Biological and Environmental Systems and New Analytical Methods for Improved Detection.International journal of molecular sciences · 2022Article
- Synthesis, Toxicity Assessment, Environmental and Biomedical Applications of MXenes: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized. Such potential toxicity must be carefully assessed with the underlying mechanisms elucidated. To that purpose, different approaches can be used. First, experimental toxicology consisting of conducting in vitro or in vivo experiments (including clinical studies) can be used to evaluate the nanomaterial hazard. It can rely on variable models (more or less complex), allowing the investigation of different biological endpoints. The respective advantages and limitations of in vitro and in vivo models are discussed as well as some issues associated with experimental nanotoxicology. Perspectives of future developments in the field are also proposed. Second, computational nanotoxicology, i.e., in silico approaches, can be used to predict nanomaterial toxicity. In this context, we describe the general principles, advantages, and limitations especially of quantitative structure-activity relationship (QSAR) models and grouping/read-across approaches. The aim of this review is to provide an overview of these different approaches based on examples and highlight their complementarity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.