Evidence map›Paper›PMID 35457828›Full record

ReviewMicromachines2022

Cancer Diagnostics and Early Detection Using Electrochemical Aptasensors.

Joel Imoukhuede Omage, Ethan Easterday, Jelonia T Rumph, Imamulhaq Brula, Braxton Hill, Jeffrey Kristensen, Dat Thinh Ha, Cristi L Galindo, Michael K Danquah, Naiya Sims and 1 more

Abstract readReview
In one paragraph

Review in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joel Imoukhuede OmageDivision of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-3896-8343
Ethan EasterdayDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Jelonia T RumphSchool of Medicine, Meharry Medical College, Nashville, TN 37208, USA.ORCID 0000-0003-2082-6355
Imamulhaq BrulaDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Braxton HillDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Jeffrey KristensenDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Dat Thinh HaCenter for Cancer Immunology and Cutaneous Biology Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Cristi L GalindoDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Michael K DanquahDepartment of Chemical Engineering, University of Tennessee, Chattanooga, TN 37403, USA.
Naiya SimsDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.
Van Thuan NguyenDepartment of Biology, Western Kentucky University, Bowling Green, KY 42101, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The detection of early-stage cancer offers patients the best chance of treatment and could help reduce cancer mortality rates. However, cancer cells or biomarkers are present in extremely small amounts in the early stages of cancer, requiring high-precision quantitative approaches with high sensitivity for accurate detection. With the advantages of simplicity, rapid response, reusability, and a low cost, aptamer-based electrochemical biosensors have received considerable attention as a promising approach for the clinical diagnosis of early-stage cancer. Various methods for developing highly sensitive aptasensors for the early detection of cancers in clinical samples are in progress. In this article, we discuss recent advances in the development of electrochemical aptasensors for the early detection of different cancer biomarkers and cells based on different detection strategies. Clinical applications of the aptasensors and future perspectives are also discussed.

Indexed as

aptameraptasensorcancer diagnosticEISelectrochemicalnanomaterials

Identifiers

PMID35457828
PMCPMC9026785

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.