ArticleMicromachines2022
A Study on Biocompatible Polymer-Based Packaging of Neural Interface for Chronic Implantation.
Article in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Biomimetic Design and Assessment via Microenvironmental Testing: From Food Packaging Biomaterials to Implantable Medical Devices.Biomimetics (Basel, Switzerland) · 2025Review
- Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording.Microsystems & nanoengineering · 2025Article
- Development of an implantable sensor system forBioactive materials · 2025Article
- Editorial for the Special Issue on Wearable and Implantable Bio-MEMS Devices and Applications.Micromachines · 2024Article
- Development of a Water Transmission Rate (WTR) Measurement System for Implantable Barrier Coatings.Polymers · 2023Article
- Development of a Three-Dimensional Nerve Stretch Growth Device towards an Implantable Neural Interface.Micromachines · 2022Article
- Article
- Mechanical Characterization and Analysis of Different-Type Polyimide Feedthroughs Based on Tensile Test and FEM Simulation for an Implantable Package.Micromachines · 2022Article
- Editorial for the Special Issue "MEMS Packaging Technologies and 3D Integration".Micromachines · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This paper proposed and verified the use of polymer-based packaging to implement the chronic implantation of neural interfaces using a combination of a commercial thermal epoxy and a thin parylene film. The packaging's characteristics and the performance of the vulnerable interface between the thermal epoxy layer and polyimide layer, which is mainly used for neural electrodes and an FPCB, were evaluated through in vitro, in vivo, and acceleration experiments. The performance of neural interfaces-composed of the combination of the thermal epoxy and thin parylene film deposition as encapsulation packaging-was evaluated by using signal acquisition experiments based on artificial stimulation signal transmissions through in vitro and in vivo experiments. It has been found that, when commercial thermal epoxy normally cured at room temperature was cured at higher temperatures of 45 °C and 65 °C, not only is its lifetime increased with about twice the room-temperature-based curing conditions but also an interfacial adhesion is higher with more than twice the room-temperature-based curing conditions. In addition, through in vivo experiments using rats, it was confirmed that bodily fluids did not flow into the interface between the thermal epoxy and FPCB for up to 18 months, and it was verified that the rats maintained healthy conditions without occurring an immune response in the body to the thin parylene film deposition on the packaging's surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.