Evidence map›Paper›PMID 35457330›Full record

Trial reportInternational journal of environmental research and public health2022

Eight Days of L-Citrulline or L-Arginine Supplementation Did Not Improve 200-m and 100-m Swimming Time Trials.

Ozcan Esen, Mustafa Can Eser, Mekki Abdioglu, Daniela Benesova, Tomasz Gabrys, Raci Karayigit

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Sport supplementation in competitive swimmers: a systematic review with meta-analysis.Journal of the International Society of Sports Nutrition · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Ozcan EsenDepartment of Health Professions, Manchester Metropolitan University, Manchester M15 6GX, UK.ORCID 0000-0003-3559-2854
Mustafa Can EserFaculty of Sport Sciences, Ankara University, Gölbaşı, Ankara 06830, Turkey.ORCID 0000-0003-1771-861X
Mekki AbdiogluFaculty of Sport Sciences, Ankara University, Gölbaşı, Ankara 06830, Turkey.
Daniela BenesovaSport Centrum Faculty of Pedagogy, University of West Bohemia, 30100 Pilsen, Czech Republic.
Tomasz GabrysSport Centrum Faculty of Pedagogy, University of West Bohemia, 30100 Pilsen, Czech Republic.
Raci KarayigitFaculty of Sport Sciences, Ankara University, Gölbaşı, Ankara 06830, Turkey.ORCID 0000-0001-9058-1918
Ankara University · TRUniversity of West Bohemia in Pilsen · CZManchester Metropolitan University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of L-citrulline or L-arginine supplementation on exercise performance are equivocal, and the effects on swimming performance are unclear. We aimed to assess whether 8-day supplementation with L-arginine or L-citrulline supplementation would improve 200 m and 100 m freestyle swimming time-trial performances. After the baseline trial (first visit), in a double-blind, randomised design, 15 trained/developmental (5 females) swimmers and triathletes were assigned to three groups and underwent an 8-day supplementation period, with a daily dose of either 8 gr L-arginine (Arg, n = 5) or L-citrulline (Cit, n = 5) or placebo (Pla, n = 5). On day 9, participants completed experimental trial (second visit). In each trial, after blood sampling, participants performed both 200 m and 100 m freestyle swimming time-trials, with 30 min recovery between trials. Plasma nitric oxide (NOx) and blood lactate concentrations (BLa) were collected immediately before and after 200 m and 100 m TTs, respectively. No significant difference was observed in NOx between groups (p = 0.201). There was no significant difference in 200 m (p = 0.226) and 100 m swimming time-trials (p = 0.993) between groups. There was a main effect of time on BLa concentration (p < 0.001), but no trial × group (p = 0.243) and trial × lactate × group interaction effect (p = 0.276) was present. Furthermore, 8-day either L-citrulline or L-arginine supplementation did not enhance middle (200 m) and short-distance (100 m) swimming performance in trained/developmental swimmers and triathletes. These findings do not support the use of L-citrulline or L-arginine supplementation as ergogenic aids for swimming performance.

Indexed as

CitrullineSwimmingArginineDietary SupplementsDouble-Blind MethodFemaleHumansLactic AcidMaleNitric OxideArginineCitrullineLactic AcidNitric Oxideergogenic aidfunctional foodsnitric oxidesport nutritionsupplements

Identifiers

PMID35457330
PMCPMC9032797
OpenAlexW4224234695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.