Evidence map›Paper›PMID 35457182›Full record

ReviewInternational journal of molecular sciences2022

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0.

Monika Ruszała, Aleksandra Pilszyk, Magdalena Niebrzydowska, Żaneta Kimber-Trojnar, Marcin Trojnar, Bożena Leszczyńska-Gorzelak

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Metabolic Roles of Fatty Acid Binding Protein 4 (FABP4) in Fetal and Maternal Health and Maintenance of Pregnancy in Women with Obesity: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Gestational Diabetes Mellitus and Colostral Appetite-Regulating Adipokines.International journal of molecular sciences · 2024
    Article
  15. Article
  16. Comprehensive Overview of the Effects ofLife (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Review
  19. The Role of Adipokines in Inflammatory Mechanisms of Obesity.International journal of molecular sciences · 2022
    Review
  20. Incretins as a Potential Treatment Option for Gestational Diabetes Mellitus.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monika RuszałaDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
Aleksandra PilszykDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0002-7250-4326
Magdalena NiebrzydowskaDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0002-9675-0919
Żaneta Kimber-TrojnarDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0001-7295-0409
Marcin TrojnarDepartment of Internal Diseases, Medical University of Lublin, 20-059 Lublin, Poland.
Bożena Leszczyńska-GorzelakDepartment of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) has become a major public health problem and one of the most discussed issues in modern obstetrics. GDM is associated with serious adverse perinatal outcomes and long-term health consequences for both the mother and child. Currently, the importance and purposefulness of finding a biopredictor that will enable the identification of women with an increased risk of developing GDM as early as the beginning of pregnancy are highly emphasized. Both "older" molecules, such as adiponectin and leptin, and "newer" adipokines, including fatty acid-binding protein 4 (FABP4), have proven to be of pathophysiological importance in GDM. Therefore, in our previous review, we presented 13 novel biomolecules, i.e., galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, FABP4, fibroblast growth factor 21, and lipocalin-2. The purpose of this review is to present the potential and importance of another nine lesser known molecules in the pathogenesis of GDM, i.e., 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), angiopoietin-like protein-8 (ANGPTL-8), nesfatin-1, afamin, adropin, fetuin-A, zonulin, secreted frizzled-related proteins (

Indexed as

Diabetes, GestationalAdipokinesAdiponectinalpha-2-HS-GlycoproteinFemaleHumansPregnancyAdipokinesAdiponectinalpha-2-HS-GlycoproteinadropinafaminANGPTL-8biomoleculesCMPFfetuin-Agestational diabetes mellitusnesfatin-1SFRPszonulin

Identifiers

PMID35457182
PMCPMC9031541
OpenAlexW4225306883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.