Evidence map›Paper›PMID 35457157›Full record

ArticleInternational journal of molecular sciences2022

Aortic Fibrosis in Insulin-Sensitive Mice with Endothelial Cell-Specific Deletion of

Raghd Abu Helal, Harrison T Muturi, Abraham D Lee, Wei Li, Hilda E Ghadieh, Sonia M Najjar

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Exploring Cirrhosis: Insights into Advances in Therapeutic Strategies.International journal of molecular sciences · 2025
    Review
  2. CEACAM1 in vascular homeostasis and inflammation.European journal of clinical investigation · 2024
    Review
  3. Article
  4. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.Metabolism: clinical and experimental · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Raghd Abu HelalDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Harrison T MuturiDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Abraham D LeeCenter for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Toledo, OH 43606, USA.
Wei LiDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25755, USA.ORCID 0000-0002-7973-6242
Hilda E GhadiehDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.ORCID 0000-0002-7983-2090
Sonia M NajjarDepartment of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Ohio University · USMarshall University · USUniversity of Balamand · LBUniversity of Toledo · US

Funding

SUBSTRATES AND INSULIN RECEPTOR ENDOCYTOSISR01DK054254 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2000 to 2021
$5.8M
Linking fat metabolism to hepatic fibrosisR01DK124126 · NIDDK · OHIO UNIVERSITY ATHENS · PI NAJJAR, SONIA M., PURI, VISHWAJEET · 2020 to 2023
$2.1M
CEACAM1: A link between metabolic and cardiovascular diseasesR01HL112248 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2012 to 2016
$1.9M
Thymidine Phosphorylase: a Novel Target of Antiplatelet TherapyR15HL145573 · NHLBI · MARSHALL UNIVERSITY · PI LI, WEI · 2019 to 2022
$878k
Insulin resistance in the pathogenesis of NASHR01DK083850 · NIDDK · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NAJJAR, SONIA M. · 2009 to 2010
$749k
NHLBI NIH HHS R15 HL145573NIH HHS R01-DK054254NIH HHS R01-DK083850NIH HHS R01DK124126NIH HHS R01-HL112248NIH HHS R15HL145573
6 · The paper itself

Abstract

(1) Background: Mice with global

Indexed as

AtherosclerosisHypercholesterolemiaInsulin ResistancePlaque, AtheroscleroticAnimalsCarcinoembryonic AntigenEndothelial CellsFibrosisInflammationInsulinInsulin, Regular, HumanMiceMice, Inbred C57BLMice, KnockoutNF-kappa BCarcinoembryonic AntigenCeacam1 protein, mouseInsulinInsulin, Regular, HumanNF-kappa Batheromafatty streaksfibrosisinflammationinsulin resistanceoxidative stress

Identifiers

PMID35457157
PMCPMC9027102
OpenAlexW4224049124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.