Evidence map›Paper›PMID 35457132›Full record

ArticleInternational journal of molecular sciences2022

Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.

Kenta Ikeda, Shin Morizane, Takahiko Akagi, Sumie Hiramatsu-Asano, Kota Tachibana, Ayano Yahagi, Masanori Iseki, Hideaki Kaneto, Jun Wada, Katsuhiko Ishihara and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. An Aqueous Extract ofInternational journal of molecular sciences · 2026
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  18. The Role of Adipokines in the Pathogenesis of Psoriasis.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kenta IkedaDepartment of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID 0000-0003-0154-5638
Shin MorizaneDepartment of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID 0000-0003-1374-065X
Takahiko AkagiDepartment of Rheumatology, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Sumie Hiramatsu-AsanoDepartment of Rheumatology, Kawasaki Medical School, Kurashiki 701-0192, Japan.ORCID 0000-0003-2653-9592
Kota TachibanaDepartment of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Ayano YahagiDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Masanori IsekiDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Hideaki KanetoDepartment of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki 701-0192, Japan.ORCID 0000-0001-7898-1943
Jun WadaDepartment of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Katsuhiko IshiharaDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki 701-0192, Japan.ORCID 0000-0002-2826-5188
Yoshitaka MoritaDepartment of Rheumatology, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Tomoyuki MukaiDepartment of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki 701-0192, Japan.ORCID 0000-0002-0103-1621
Kawasaki Medical School · JPOkayama University · JP

Funding

Eli Lilly (Japan) Eli Lilly Japan KK Research Grant 2021Health Labour Sciences Research Grant 20FC1047Japan Society for the Promotion of Science 20K08672Japan Society for the Promotion of Science 20K17442Japan Society for the Promotion of Science 21K08484Kawasaki Medical School R03B-046Mishima Kaiun Memorial Foundation N/AUCB Japan N/A
6 · The paper itself

Abstract

Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis. To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal keratinocytes (NHEKs), we used wild-type and

Indexed as

DermatitisDyslipidemiasPsoriasisAnimalsHumansInflammationInterleukin-17KeratinocytesLeptinMiceObesityPalmitic AcidSkinTumor Necrosis Factor-alphaInterleukin-17LeptinPalmitic AcidTumor Necrosis Factor-alphachemokinedyslipidemialeptinobesitypalmitic acidpsoriasis

Identifiers

PMID35457132
PMCPMC9032572
OpenAlexW4224138674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.