ArticleInternational journal of molecular sciences2022
Preparation and Characterization of Plasma-Derived Fibrin Hydrogels Modified by Alginate di-Aldehyde.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Strategies and Technologies for Comprehensive Characterization of Hydrogel-Based Materials in the Biomedical Field.Polymers · 2026Review
- 3D-Printed Alginate Dialdehyde (ADA)-Gelatin (GEL) Hydrogels with Gallic Acid (GA) for Enhanced Multifunctional Properties.ACS omega · 2026Article
- Succinimidyl Alginate-Modified Fibrin Hydrogels from Human Plasma for Skin Tissue Engineering.Gels (Basel, Switzerland) · 2025Article
- Hydrogel-Based Scaffolds: Advancing Bone Regeneration Through Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Formulation and Characterization of a Novel Oxidized Alginate-Gelatin-Silk Fibroin Bioink with the Aim of Skin Regeneration.Iranian biomedical journal · 2023Article
- Plasma-Derived Fibrin Hydrogels Containing Graphene Oxide for Infections Treatment.ACS materials letters · 2023Article
- Article
- Matrices Activated with Messenger RNA.Journal of functional biomaterials · 2023Review
- Multifunctional Oxidized Succinoglycan/Poly(N-isopropylacrylamide-co-acrylamide) Hydrogels for Drug Delivery.Polymers · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrin hydrogels are one of the most popular scaffolds used in tissue engineering due to their excellent biological properties. Special attention should be paid to the use of human plasma-derived fibrin hydrogels as a 3D scaffold in the production of autologous skin grafts, skeletal muscle regeneration and bone tissue repair. However, mechanical weakness and rapid degradation, which causes plasma-derived fibrin matrices to shrink significantly, prompted us to improve their stability. In our study, plasma-derived fibrin was chemically bonded to oxidized alginate (alginate di-aldehyde, ADA) at 10%, 20%, 50% and 80% oxidation, by Schiff base formation, to produce natural hydrogels for tissue engineering applications. First, gelling time studies showed that the degree of ADA oxidation inhibits fibrin polymerization, which we associate with fiber increment and decreased fiber density; moreover, the storage modulus increased when increasing the final volume of CaCl
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Registered trials
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