Evidence map›Paper›PMID 35457096›Full record

ArticleInternational journal of molecular sciences2022

Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells.

Maria João Bessa, Fátima Brandão, Paul H B Fokkens, Daan L A C Leseman, A John F Boere, Flemming R Cassee, Apostolos Salmatonidis, Mar Viana, Eliseo Monfort, Sónia Fraga and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Maria João BessaDepartment of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-053 Porto, Portugal.ORCID 0000-0001-5357-6167
Fátima BrandãoDepartment of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-053 Porto, Portugal.ORCID 0000-0002-2933-8561
Paul H B FokkensNational Institute for Public Health and Environment (RIVM), 3721 Bilthoven, The Netherlands.
Daan L A C LesemanNational Institute for Public Health and Environment (RIVM), 3721 Bilthoven, The Netherlands.
A John F BoereNational Institute for Public Health and Environment (RIVM), 3721 Bilthoven, The Netherlands.
Flemming R CasseeNational Institute for Public Health and Environment (RIVM), 3721 Bilthoven, The Netherlands.
Apostolos SalmatonidisInstitute of Environmental Assessment and Water Research, Spanish Research Council (IDAEA-CSIC), 08034 Barcelona, Spain.
Mar VianaInstitute of Environmental Assessment and Water Research, Spanish Research Council (IDAEA-CSIC), 08034 Barcelona, Spain.ORCID 0000-0002-4073-3802
Eliseo MonfortInstitute of Ceramic Technology (ITC), Universitat Jaume I, 12006 Castellón, Spain.
Sónia FragaDepartment of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-053 Porto, Portugal.
João Paulo TeixeiraDepartment of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-053 Porto, Portugal.ORCID 0000-0001-8693-5250
Universidade do Porto · PTNational Institute for Public Health and the Environment · NLInstitute of Environmental Assessment and Water Research · ESLeitat Technological Center · ESUniversitat Jaume I · ESUtrecht University · NL

Funding

ERA-NET SIINN project id:16Fundação para a Ciência e Tecnologia DL-57/INSA-06/2018Fundação para a Ciência e Tecnologia LA/P/0064/2020Fundação para a Ciência e Tecnologia PTDC/MED-TOX/31162/2017Fundação para a Ciência e Tecnologia SFRH/BD/101060/2014Fundação para a Ciência e Tecnologia SFRH/BD/120646/2016Fundação para a Ciência e Tecnologia SIINN/0004/2014Fundação para a Ciência e Tecnologia UIDB/04750/2020Spanish Ministry of Science and Innovation CEX2018-000794-S-Severo OchoaSpanish Ministry of Science and Innovation PCIN-2015-173-C02-01
6 · The paper itself

Abstract

High-energy industrial processes have been associated with particle release into workplace air that can adversely affect workers' health. The present study assessed the toxicity of incidental fine (PGFP) and nanoparticles (PGNP) emitted from atmospheric plasma (APS) and high-velocity oxy-fuel (HVOF) thermal spraying. Lactate dehydrogenase (LDH) release, 2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1) metabolisation, intracellular reactive oxygen species (ROS) levels, cell cycle changes, histone H2AX phosphorylation (γ-H2AX) and DNA damage were evaluated in human alveolar epithelial cells at 24 h after exposure. Overall, HVOF particles were the most cytotoxic to human alveolar cells, with cell viability half-maximal inhibitory concentration (IC

Indexed as

Alveolar Epithelial CellsDNA DamageCell SurvivalEpithelial CellsHumansOxidative StressParticle SizeReactive Oxygen SpeciesReactive Oxygen SpeciesA549 cellscell cyclecytotoxicityDNA damageH2AX phosphorylationincidental nanoparticlesin vitro toxicityoccupational exposureprocess-generated nanoparticles

Identifiers

PMID35457096
PMCPMC9025379
OpenAlexW4224060341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.