Evidence map›Paper›PMID 35457064›Full record

ArticleInternational journal of molecular sciences2022

Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in

Daniel S Yang, Edward E Dickerson, Ling X Zhang, Holly Richendrfer, Padmini N Karamchedu, Gary J Badger, Tannin A Schmidt, Alger M Fredericks, Khaled A Elsaid, Gregory D Jay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Daniel S YangSchool of Engineering, Brown University, Providence, RI 02912, USA.
Edward E DickersonNorth Carolina Agricultural Technical State University, Greensboro, NC 27411, USA.
Ling X ZhangDepartment of Emergency Medicine, Alpert School of Medicine, Brown University, Providence, RI 02903, USA.
Holly RichendrferDepartment of Emergency Medicine, Alpert School of Medicine, Brown University, Providence, RI 02903, USA.
Padmini N KaramcheduDepartment of Orthopedics, Alpert School of Medicine, Brown University, Providence, RI 02903, USA.
Gary J BadgerDepartment of Medical Biostatistics, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Tannin A SchmidtDepartment of Biomedical Engineering, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA.ORCID 0000-0001-7140-254X
Alger M FredericksDepartment of Surgery, Alpert School of Medicine, Brown University, Providence, RI 02903, USA.
Khaled A ElsaidSchool of Pharmacy, Chapman University, Irvine, CA 92618, USA.ORCID 0000-0002-8925-4255
Gregory D JaySchool of Engineering, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-1517-8488
Brown University · USChapman University · USNorth Carolina Agricultural and Technical State University · USUConn Health · USUniversity of Vermont · US

Funding

Non-tribologic Bioactivity of LubricinR01AR067748 · NIAMS · RHODE ISLAND HOSPITAL · PI ELSAID, KHALED AHMED, JAY, GREGORY D. · 2016 to 2020
$2.2M
NIAMS NIH HHS R01AR067748
6 · The paper itself

Abstract

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4-PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. In this study, mice lacking the orthologous gene

Indexed as

Cartilage, ArticularJoint DiseasesOsteoarthritisAnimalsArthropathy, NeurogenicCaspase 3Coxa VaraFemaleGaitHand Deformities, CongenitalInjections, Intra-ArticularMaleMiceMice, KnockoutProteoglycan 4ProteoglycansCaspase 3Prg4 protein, mouseProteoglycan 4ProteoglycansarthritisarthrosisCACPcollagen hybridizing peptidelubricinPrg4−/−PRG4rhPRG4

Identifiers

PMID35457064
PMCPMC9025840
OpenAlexW4223459906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.