Evidence map›Paper›PMID 35457048›Full record

ArticleInternational journal of molecular sciences2022

Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes.

Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. AdultBiomolecules · 2026
    Article
  3. Type 2 Diabetes From the Perspective of Telomere Biology.Endocrinology, diabetes & metabolism · 2026
    Review
  4. Methods and protocols · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kosuke OtaniLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan.
Hiroshi FunadaLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan.
Risa TeranishiLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan.
Muneyoshi OkadaLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan.ORCID 0000-0002-0746-206X
Hideyuki YamawakiLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Aomori, Japan.
Kitasato University · JP

Funding

Nishinomiya Basic Research Fund N/A
6 · The paper itself

Abstract

Zucker fatty diabetes mellitus (ZFDM) rats harboring the missense mutation (fa) in a leptin receptor gene have been recently established as a novel animal model of obesity and type 2 diabetes (T2D). Here, we explored changes in cardiovascular dynamics including blood pressure and heart rate (HR) associated with the progression of obesity and T2D, as well as pathological changes in adipose tissue and kidney. There was no significant difference in systolic blood pressure (SBP) in ZFDM-Lepr

Indexed as

Diabetes Mellitus, Type 2Adipose TissueAdipose Tissue, BrownAnimalsDisease Models, AnimalEpinephrineObesityRatsRats, ZuckerEpinephrineadipose tissuecardiovascular dynamicsdiabeteskidneyobesitysympathetic nerve activity

Identifiers

PMID35457048
PMCPMC9027163
OpenAlexW4223535567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.