Evidence map›Paper›PMID 35457002›Full record

ReviewInternational journal of molecular sciences2022

Molecular Dynamics and Evolution of Centromeres in the Genus Equus.

Francesca M Piras, Eleonora Cappelletti, Marco Santagostino, Solomon G Nergadze, Elena Giulotto, Elena Raimondi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The dynamic centromere.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. A Satellite-Free Centromere inInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Francesca M PirasDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-7418-3976
Eleonora CappellettiDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-0004-2193
Marco SantagostinoDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-8777-3641
Solomon G NergadzeDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-8121-0189
Elena GiulottoDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-4705-2049
Elena RaimondiDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-6781-0137
University of Pavia · IT

Funding

Ministry of Education, Universities and Research Dipartimenti di Eccellenza Program (2018-2022)-Dept. of Biology and Biotechnology "L. Spallanzani", University of Pavia)Ministry of Education, Universities and Research PRIN Grant No. 2015RA7XZS_002National Research Council Progetto Bandiera Epigenomica
6 · The paper itself

Abstract

The centromere is the chromosomal locus essential for proper chromosome segregation. While the centromeric function is well conserved and epigenetically specified, centromeric DNA sequences are typically composed of satellite DNA and represent the most rapidly evolving sequences in eukaryotic genomes. The presence of satellite sequences at centromeres hampered the comprehensive molecular analysis of these enigmatic loci. The discovery of functional centromeres completely devoid of satellite repetitions and fixed in some animal and plant species represented a turning point in centromere biology, definitively proving the epigenetic nature of the centromere. The first satellite-free centromere, fixed in a vertebrate species, was discovered in the horse. Later, an extraordinary number of satellite-free neocentromeres had been discovered in other species of the genus Equus, which remains the only mammalian genus with numerous satellite-free centromeres described thus far. These neocentromeres arose recently during evolution and are caught in a stage of incomplete maturation. Their presence made the equids a unique model for investigating, at molecular level, the minimal requirements for centromere seeding and evolution. This model system provided new insights on how centromeres are established and transmitted to the progeny and on the role of satellite DNA in different aspects of centromere biology.

Indexed as

DNA, SatelliteMolecular Dynamics SimulationAnimalsCentromereChromosome SegregationEvolution, MolecularHorsesMammalsDNA, SatelliteCENP-Acentromere repositioningcentromere slidinggenus Equuskaryotype evolutionneocentromeressatellite DNA

Identifiers

PMID35457002
PMCPMC9024551
OpenAlexW4223586814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.