Evidence map›Paper›PMID 35456975›Full record

ArticleInternational journal of molecular sciences2022

Recognition of a Novel Gene Signature for Human Glioblastoma.

Chih-Hao Lu, Sung-Tai Wei, Jia-Jun Liu, Yu-Jen Chang, Yu-Feng Lin, Chin-Sheng Yu, Sunny Li-Yun Chang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  8. Review
  9. Artificial Intelligence-Driven Multi-Omics Approaches in Glioblastoma.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chih-Hao LuThe Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-8363-6244
Sung-Tai WeiDepartment of Neurosurgery, China Medical University Hospital, Taichung 404332, Taiwan.
Jia-Jun LiuThe Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung 404333, Taiwan.
Yu-Jen ChangThe Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung 404333, Taiwan.
Yu-Feng LinDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413305, Taiwan.ORCID 0000-0003-1998-3310
Chin-Sheng YuDepartment of Information Engineering and Computer Science, Feng Chia University, Taichung 407102, Taiwan.
Sunny Li-Yun ChangGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
China Medical University · TWAsia University · TWFeng Chia University · TW

Funding

China Medical University, Taiwan CMU110-ASIA-07
6 · The paper itself

Abstract

Glioblastoma (GBM) is one of the most common malignant and incurable brain tumors. The identification of a gene signature for GBM may be helpful for its diagnosis, treatment, prediction of prognosis and even the development of treatments. In this study, we used the GSE108474 database to perform GSEA and machine learning analysis, and identified a 33-gene signature of GBM by examining astrocytoma or non-GBM glioma differential gene expression. The 33 identified signature genes included the overexpressed genes

Indexed as

Brain NeoplasmsGlioblastomaGliomaBiomarkers, TumorDNA-Binding ProteinsExtracellular Matrix ProteinsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansIntercellular Signaling Peptides and ProteinsLIM Domain ProteinsMembrane ProteinsNeoplasm ProteinsPeroxidasesSulfotransferasesBiomarkers, TumorCHST9 protein, humanCTHRC1 protein, humanDNA-Binding ProteinsEnho protein, humanExtracellular Matrix ProteinsFERMT1 protein, humanGPX8 protein, humanIntercellular Signaling Peptides and ProteinsLIM Domain ProteinsMembrane ProteinsNeoplasm ProteinsPDLIM4 protein, humanPeroxidasesSulfotransferasesastrocytomabiomarker signaturegene signatureglioblastomagliomamachine learningoligodendrocytomasurvival

Identifiers

PMID35456975
PMCPMC9029857
OpenAlexW4224290548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.