ArticleInternational journal of molecular sciences2022
Cytomolecular Classification of Thyroid Nodules Using Fine-Needle Washes Aspiration Biopsies.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Boosting thyroid nodule diagnosis through ultrasound and molecular imaging integration with unsupervised learning.Quantitative imaging in medicine and surgery · 2026Article
- Syncretic Grad-CAM Integrated ViT-CNN Hybrids with Inherent Explainability for Early Thyroid Cancer Diagnosis from Ultrasound.Diagnostics (Basel, Switzerland) · 2026Article
- Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications.Precision clinical medicine · 2026Review
- Artificial intelligence in thyroid ultrasound: clinical applications and perspectives.Frontiers in endocrinology · 2026Review
- Malignancy prediction for calcified thyroid nodules using deep learning based on ultrasound dynamic videos.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Biomarker identification through spatial proteomics for the characterization of indeterminate thyroid nodules.Endocrine · 2025Article
- Towards an Integrated Multi-Omic Approach to Improve the Diagnostic Accuracy of Fine-Needle Aspiration in Thyroid Nodules with Indeterminate Cytology.Diagnostics (Basel, Switzerland) · 2025Review
- Application progress of artificial intelligence in managing thyroid disease.Frontiers in endocrinology · 2025Review
- Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs).International journal of molecular sciences · 2023Article
- The application of high-throughput proteomics in cytopathology.Journal of pathology and translational medicine · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Fine-needle aspiration biopsies (FNA) represent the gold standard to exclude the malignant nature of thyroid nodules. After cytomorphology, 20-30% of cases are deemed "indeterminate for malignancy" and undergo surgery. However, after thyroidectomy, 70-80% of these nodules are benign. The identification of tools for improving FNA's diagnostic performances is explored by matrix-assisted laser-desorption ionization mass spectrometry imaging (MALDI-MSI). A clinical study was conducted in order to build a classification model for the characterization of thyroid nodules on a large cohort of 240 samples, showing that MALDI-MSI can be effective in separating areas with benign/malignant cells. The model had optimal performances in the internal validation set (
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