Evidence map›Paper›PMID 35456861›Full record

ReviewMicroorganisms2022

The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives.

Juan de Dios Caballero, Rafael Cantón, Manuel Ponce-Alonso, Marta María García-Clemente, Elia Gómez G de la Pedrosa, José Luis López-Campos, Luis Máiz, Rosa Del Campo, Miguel Ángel Martínez-García

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  6. Correlation BetweenJournal of fungi (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Immunopathologic Role of Fungi in Chronic Rhinosinusitis.International journal of molecular sciences · 2023
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Juan de Dios CaballeroDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain.
Rafael CantónDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain.ORCID 0000-0003-1675-3173
Manuel Ponce-AlonsoDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain.ORCID 0000-0002-3239-9373
Marta María García-ClementeDepartment of Pneumology, Central Asturias University Hospital, 33011 Oviedo, Spain.ORCID 0000-0003-0463-5946
Elia Gómez G de la PedrosaDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain.
José Luis López-CamposMedical-Surgical Unit for Respiratory Diseases (CIBERES), Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, University of Seville, 41013 Sevilla, Spain.
Luis MáizCIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain.
Rosa Del CampoDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain.ORCID 0000-0003-1147-7923
Miguel Ángel Martínez-GarcíaCIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-7321-1891
Instituto Cajal · ESInstituto de Salud Carlos III · ESHospital Universitario Central de Asturias · ES

Funding

Instituto de Salud Carlos III CB21/13/00084Instituto de Salud Carlos III CM19/00069Instituto de Salud Carlos III JR18/00034Instituto de Salud Carlos III PI17/00115Instituto de Salud Carlos III PI19/01043Instituto de Salud Carlos III RD16/0016/0011
6 · The paper itself

Abstract

Microbes play an important role in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, non-cystic fibrosis bronchiectasis, and asthma. While the role of bacterial pathogens has been extensively studied, the contribution of fungal species to the pathogenesis of chronic lung diseases is much less understood. The recent introduction of next-generation sequencing techniques has revealed the existence of complex microbial lung communities in healthy individuals and patients with chronic respiratory disorders, with fungi being an important part of these communities' structure (mycobiome). There is growing evidence that the components of the lung mycobiome influence the clinical course of chronic respiratory diseases, not only by direct pathogenesis but also by interacting with bacterial species and with the host's physiology. In this article, we review the current knowledge on the role of fungi in chronic respiratory diseases, which was obtained by conventional culture and next-generation sequencing, highlighting the limitations of both techniques and exploring future research areas.

Indexed as

cross-kingdom interactionsfungal pathogenesismicrobiomemycobiomenext-generation sequencing

Identifiers

PMID35456861
PMCPMC9029612
OpenAlexW4224048096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.