Evidence map›Paper›PMID 35456768›Full record

ReviewMicroorganisms2022

Essential Topics for the Regulatory Consideration of Phages as Clinically Valuable Therapeutic Agents: A Perspective from Spain.

Roberto Vázquez, Roberto Díez-Martínez, Pilar Domingo-Calap, Pedro García, Diana Gutiérrez, Maite Muniesa, María Ruiz-Ruigómez, Rafael Sanjuán, María Tomás, María Ángeles Tormo-Mas and 1 more

Abstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. P3MA: A Promising Mycobacteriophage InfectingAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Efficacy ofMicrobiology spectrum · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. In Vitro Susceptibility of Clinical and Carrier Strains ofInternational journal of molecular sciences · 2024
    Article
  14. Review
  15. Review
  16. Review
  17. Phage therapy: breathing new tactics into lower respiratory tract infection treatments.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Roberto VázquezDepartment of Biotechnology, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-7919-552X
Roberto Díez-MartínezTelum Therapeutics SL, 31110 Noáin, Spain.ORCID 0000-0001-8007-8163
Pilar Domingo-CalapInstitute for Integrative Systems Biology, University of Valencia-CSIC, 46980 Paterna, Spain.ORCID 0000-0003-2829-8809
Pedro GarcíaCenter for Biological Research Margarita Salas (CIB-CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28040 Madrid, Spain.
Diana GutiérrezTelum Therapeutics SL, 31110 Noáin, Spain.
Maite MuniesaDepartment of Genetics, Microbiology and Statistics, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-5549-1394
María Ruiz-RuigómezInternal Medicine, Infectious Diseases Unit, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0003-1538-3043
Rafael SanjuánInstitute for Integrative Systems Biology, University of Valencia-CSIC, 46980 Paterna, Spain.ORCID 0000-0002-1844-545X
María TomásDepartment of Microbiology, Hospital Universitario de A Coruña (INIBIC-CHUAC, SERGAS), 15006 A Coruña, Spain.ORCID 0000-0003-4501-0387
María Ángeles Tormo-MasSevere Infection Group, Hospital Universitari i Politècnic La Fe, Health Research Institute Hospital La Fe, IISLaFe, 46026 Valencia, Spain.ORCID 0000-0001-8928-2697
Pilar GarcíaDairy Research Institute of Asturias, IPLA-CSIC, 33300 Villaviciosa, Spain.ORCID 0000-0003-1213-8165

Funding

MCIN/AEI/ 10.13039/501100011033 RED2018-102589-TMCIN/AEI/10.13039/501100011033 PID2020-112835RA-I00Research Foundation - Flanders (FWO) G066919NSpanish Ministry of Science and Innovation SAF2017- 82251-RSpanish Ministry of Science and Innovation SAF2017-88664-RSpanish Ministry of Science and Innovation /Agencia Estatal de Investigación (AEI)/European regional fund (ERF) PID2020-113355GB-I00
6 · The paper itself

Abstract

Antibiotic resistance is one of the major challenges that humankind shall face in the short term. (Bacterio)phage therapy is a valuable therapeutic alternative to antibiotics and, although the concept is almost as old as the discovery of phages, its wide application was hindered in the West by the discovery and development of antibiotics in the mid-twentieth century. However, research on phage therapy is currently experiencing a renaissance due to the antimicrobial resistance problem. Some countries are already adopting new ad hoc regulations to favor the short-term implantation of phage therapy in clinical practice. In this regard, the Phage Therapy Work Group from FAGOMA (Spanish Network of Bacteriophages and Transducing Elements) recently contacted the Spanish Drugs and Medical Devices Agency (AEMPS) to promote the regulation of phage therapy in Spain. As a result, FAGOMA was asked to provide a general view on key issues regarding phage therapy legislation. This review comes as the culmination of the FAGOMA initiative and aims at appropriately informing the regulatory debate on phage therapy.

Indexed as

antimicrobial resistancebacteriophagescompassionate usedrug regulationendolysinsphage therapy

Identifiers

PMID35456768
PMCPMC9025261

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.