Evidence map›Paper›PMID 35456704›Full record

ReviewPharmaceutics2022

Recent Fabrication Methods to Produce Polymer-Based Drug Delivery Matrices (Experimental and In Silico Approaches).

Anna Procopio, Elena Lagreca, Rezvan Jamaledin, Sara La Manna, Brunella Corrado, Concetta Di Natale, Valentina Onesto

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna ProcopioBiomechatronics Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
Elena LagrecaDepartment of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-0500-8610
Rezvan JamaledinDepartment of Chemical, Materials & Industrial Production Engineering, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-2389-3393
Sara La MannaDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-7762-0708
Brunella CorradoInterdisciplinary Research Centre on Biomaterials (CRIB), University of Naples Federico II, 80131 Naples, Italy.
Concetta Di NataleIstituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.
Valentina OnestoInstitute of Nanotechnology, National Research Council (CNR-Nanotec), Campus Ecotekne, Via Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-2308-4126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of novel drug delivery systems represents one of the frontiers of the biomedical research area. Multi-disciplinary scientific approaches combining traditional or engineered technologies are used to provide major advances in improving drug bioavailability, rate of release, cell/tissue specificity and therapeutic index. Biodegradable and bio-absorbable polymers are usually the building blocks of these systems, and their copolymers are employed to create delivery components. For example, poly (lactic acid) or poly (glycolic acid) are often used as bricks for the production drug-based delivery systems as polymeric microparticles (MPs) or micron-scale needles. To avoid time-consuming empirical approaches for the optimization of these formulations, in silico-supported models have been developed. These methods can predict and tune the release of different drugs starting from designed combinations. Starting from these considerations, this review has the aim of investigating recent approaches to the production of polymeric carriers and the combination of in silico and experimental methods as promising platforms in the biomedical field.

Indexed as

in silico approachesmicro and nano encapsulationmicrofluidicsmicroneedlespolymers

Identifiers

PMID35456704
PMCPMC9027538

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.