Evidence map›Paper›PMID 35456667›Full record

ReviewPharmaceutics2022

Ultrasound-Mediated Blood-Brain Barrier Disruption for Drug Delivery: A Systematic Review of Protocols, Efficacy, and Safety Outcomes from Preclinical and Clinical Studies.

Kushan Gandhi, Anita Barzegar-Fallah, Ashik Banstola, Shakila B Rizwan, John N J Reynolds

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kushan GandhiDepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-5784-0110
Anita Barzegar-FallahDepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-7323-4313
Ashik BanstolaDepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-2842-5567
Shakila B RizwanBrain Health Research Centre, University of Otago, Dunedin 9016, New Zealand.
John N J ReynoldsDepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-5924-4865

Funding

Ministry of Business, Innovation and Employment UOOX1602
6 · The paper itself

Abstract

Ultrasound-mediated blood-brain barrier (BBB) disruption has garnered focus as a method of delivering normally impenetrable drugs into the brain. Numerous studies have investigated this approach, and a diverse set of ultrasound parameters appear to influence the efficacy and safety of this approach. An understanding of these findings is essential for safe and reproducible BBB disruption, as well as in identifying the limitations and gaps for further advancement of this drug delivery approach. We aimed to collate and summarise protocols and parameters for achieving ultrasound-mediated BBB disruption in animal and clinical studies, as well as the efficacy and safety methods and outcomes associated with each. A systematic search of electronic databases helped in identifying relevant, included studies. Reference lists of included studies were further screened to identify supplemental studies for inclusion. In total, 107 articles were included in this review, and the following parameters were identified as influencing efficacy and safety outcomes: microbubbles, transducer frequency, peak-negative pressure, pulse characteristics, and the dosing of ultrasound applications. Current protocols and parameters achieving ultrasound-mediated BBB disruption, as well as their associated efficacy and safety outcomes, are identified and summarised. Greater standardisation of protocols and parameters in future preclinical and clinical studies is required to inform robust clinical translation.

Indexed as

blood–brain barrier openingfocused ultrasoundreviewtherapeutic agent deliveryultrasound parametersultrasound safety

Identifiers

PMID35456667
PMCPMC9029131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.