Evidence map›Paper›PMID 35456652›Full record

ArticlePharmaceutics2022

Comparative Study of Powder Carriers Physical and Structural Properties.

Klára Kostelanská, Barbora Blahová Prudilová, Sylva Holešová, Jakub Vlček, David Vetchý, Jan Gajdziok

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Klára KostelanskáDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého Třída 1946/1, 612 00 Brno, Czech Republic.
Barbora Blahová PrudilováDepartment of Physical Chemistry, Faculty of Science, Palacký University Olomouc, Tř. 17. Listopadu 1192/12, 771 46 Olomouc, Czech Republic.
Sylva HolešováNanotechnology Centre, CEET, VŠB-Technical University of Ostrava, 17. Listopadu 2172/15, 708 00 Ostrava, Czech Republic.ORCID 0000-0001-5233-5847
Jakub VlčekDepartment of Physical Chemistry, Faculty of Science, Palacký University Olomouc, Tř. 17. Listopadu 1192/12, 771 46 Olomouc, Czech Republic.ORCID 0000-0002-8251-9142
David VetchýDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého Třída 1946/1, 612 00 Brno, Czech Republic.
Jan GajdziokDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého Třída 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0001-5599-5648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High specific surface area (SSA), porous structure, and suitable technological characteristics (flow, compressibility) predetermine powder carriers to be used in pharmaceutical technology, especially in the formulation of liquisolid systems (LSS) and solid self-emulsifying delivery systems (s-SEDDS). Besides widely used microcrystalline cellulose, other promising materials include magnesium aluminometasilicates, mesoporous silicates, and silica aerogels. Clay minerals with laminar or fibrous internal structures also provide suitable properties for liquid drug incorporation. This work aimed at a comparison of 14 carriers' main properties. Cellulose derivatives, silica, silicates, and clay minerals were evaluated for flow properties, shear cell experiments, SSA, hygroscopicity, pH, particle size, and SEM. The most promising materials were magnesium aluminometasilicates, specifically Neusilin

Indexed as

adsorptionaluminometasilicatesliquisolid systemspharmaceutical technologypowder carrierssolid dosage form

Identifiers

PMID35456652
PMCPMC9032780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.