Evidence map›Paper›PMID 35456600›Full record

ArticlePharmaceutics2022

Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems.

Huan Yu, Yanfei Zhang, Yinghui Ma, Huifeng Zhang, Chengyi Hao, Yong Zhang, Zhengqiang Li, Xianrong Qi, Nianqiu Shi

Abstract read
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In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan YuSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yanfei ZhangSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yinghui MaSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Huifeng ZhangSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Chengyi HaoSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yong ZhangCollege of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.ORCID 0000-0001-6577-5235
Zhengqiang LiCollege of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Xianrong QiDepartment of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing 100191, China.ORCID 0000-0002-8264-0794
Nianqiu ShiSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.

Funding

College Students' Innovation Project of Jilin Province 202013706026Doctoral Research Startup Fund Project of Jilin Medical University JYBS2021002LKNational Natural Science Foundation of China 81602654National Natural Science Foundation of China 82172593Science and Technology Development Program of Jilin City in Jilin Province of China 201831739Science and Technology Development Program of Jilin City in Jilin Province of China 20200104067Science and Technology Development Program of Jilin Province of China 20160520046JHScience and Technology Development Program of Jilin Province of China 20210101430JCScientific Research Foundation of the Education Department of Jilin Province of China 2015-401Scientific Research Foundation of the Education Department of Jilin Province of China JJKH20191072KJ
6 · The paper itself

Abstract

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs generation, HME-triggered continuous processes offer advantages over traditional non-continuous processes such as fusion/quench cooling (FQC) and co-precipitation (CP). Here we employed HME, FQC, and CP to generate saSMSDs containing the water-insoluble BCS II drug nitrendipine (NIT) and self-micellizing polymer Soluplus

Indexed as

continuous manufacturing processcrystallization inhibition and stabilization of amorphismextended supersaturable immediate releasehot melt extrusion (HME)-triggered amorphization“spring-parachute” processessupersaturating amorphous self-micellizing solid dispersions (saSMSDs)

Identifiers

PMID35456600
PMCPMC9029276

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.