Evidence map›Paper›PMID 35456437›Full record

ReviewGenes2022

Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature.

Sihle E Mabhida, Babu Muhamed, Jyoti R Sharma, Teke Apalata, Sibusiso Nomatshila, Lawrence Mabasa, Mongi Benjeddou, Charity Masilela, Khanyisani Ziqubu, Samukelisiwe Shabalala and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Association betweenPeerJ · 2025
    Article
  2. No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. The association ofFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sihle E MabhidaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.
Babu MuhamedDivision of Infections Disease, University of Tennessee Health Sciences Center (UTHSC), Memphis, TN 38163, USA.
Jyoti R SharmaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0003-0170-7342
Teke ApalataDivision of Medical Microbiology, Department of Laboratory-Medicine and Pathology, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa.
Sibusiso NomatshilaDivision of Preventive Medicine and Health Behavior, Department of Public Health, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa.ORCID 0000-0003-4130-0707
Lawrence MabasaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0001-6499-3396
Mongi BenjeddouDepartment of Biotechnology, Faculty of Natural Science, University of the Western Cape, Private Bag X17, Bellville, Cape Town 7535, South Africa.ORCID 0000-0002-0124-319X
Charity MasilelaDepartment of Biochemistry, North-West University, Mafikeng Campus, Mmabatho 2735, South Africa.
Khanyisani ZiqubuDepartment of Biochemistry, North-West University, Mafikeng Campus, Mmabatho 2735, South Africa.
Samukelisiwe ShabalalaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0003-1238-4673
Rabia JohnsonBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South Africa.ORCID 0000-0002-6328-0789
South African Medical Research Council · ZANational Health Laboratory Service · ZANorth-West University · ZAUniversity of Tennessee Health Science Center · USUniversity of the Western Cape · ZAWalter Sisulu University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (

Indexed as

HypertensionMethylenetetrahydrofolate Reductase (NADPH2)Black PeopleGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideRisk FactorsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanAfricagenetic variationHypertensionmethylenetetrahydrofolate reductase geneMTHFRsingle-nucleotide polymorphism

Identifiers

PMID35456437
PMCPMC9027465
OpenAlexW4224320347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.