Evidence map›Paper›PMID 35456405›Full record

ReviewGenes2022

Pharmacogenomics: A Step forward Precision Medicine in Childhood Asthma.

Giuliana Ferrante, Salvatore Fasola, Velia Malizia, Amelia Licari, Giovanna Cilluffo, Giorgio Piacentini, Stefania La Grutta

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Giuliana FerranteDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy.
Salvatore FasolaInstitute of Translational Pharmacology, National Research Council, 90146 Palermo, Italy.ORCID 0000-0002-5378-5505
Velia MaliziaInstitute of Translational Pharmacology, National Research Council, 90146 Palermo, Italy.
Amelia LicariDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-1773-6482
Giovanna CilluffoDepartment of Earth and Marine Sciences, University of Palermo, 90123 Palermo, Italy.ORCID 0000-0003-4305-3981
Giorgio PiacentiniDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy.
Stefania La GruttaInstitute of Translational Pharmacology, National Research Council, 90146 Palermo, Italy.ORCID 0000-0001-8026-0715
Istituto di Farmacologia Traslazionale · ITUniversity of Verona · ITUniversity of Palermo · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Personalized medicine, an approach to care in which individual characteristics are used for targeting interventions and maximizing health outcomes, is rapidly becoming a reality for many diseases. Childhood asthma is a heterogeneous disease and many children have uncontrolled symptoms. Therefore, an individualized approach is needed for improving asthma outcomes in children. The rapidly evolving fields of genomics and pharmacogenomics may provide a way to achieve asthma control and reduce future risks in children with asthma. In particular, pharmacogenomics can provide tools for identifying novel molecular mechanisms and biomarkers to guide treatment. Emergent high-throughput technologies, along with patient pheno-endotypization, will increase our knowledge of several molecular mechanisms involved in asthma pathophysiology and contribute to selecting and stratifying appropriate treatment for each patient.

Indexed as

AsthmaPharmacogeneticsBiomarkersChildGenomicsHumansPrecision MedicineBiomarkersasthmachildrencorticosteroidsgeneticsleukotriene antagonistspharmacogenomicstreatmentβ2-agonists

Identifiers

PMID35456405
PMCPMC9031013
OpenAlexW4220901673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.