ArticleJournal of clinical medicine2022
Neurological Music Therapy Rebuilds Structural Connectome after Traumatic Brain Injury: Secondary Analysis from a Randomized Controlled Trial.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01956136 (Efficacy and Neural Basis of Music-based Neurological Rehabilitation for Traumatic Brain Injury), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Neural Basis of Music-based Neurological Rehabilitation for Traumatic Brain Injury
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.Frontiers in neurologyPooled it
- [Application and perspective of novel auditory intervention paradigms based on verbal and nonverbal stimuli for severe traumatic brain injury].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Healing Effects of Music, Healing Frequencies, and Binaural Beats for Traumatic Brain Injury and Stroke: A Review.Cureus · 2026Review
- Mechanisms of action and advances in application of music therapy in improving cognitive impairment based on the theory of neuroplasticity.Frontiers in neuroscience · 2026Review
- Article
- Systematic review and meta-analysis reveal positive therapeutic effects of music in brain damage rehabilitation.Frontiers in integrative neuroscience · 2026Review
- Auditory cognition lab: a music therapy and speech-language pathology co-treatment for military-connected populations with auditory and cognitive impairment.Frontiers in neurology · 2025Article
- Review
- Non-pharmacological interventions for traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Does Music Therapy Improve Gait after Traumatic Brain Injury and Spinal Cord Injury? A Mini Systematic Review and Meta-Analysis.Brain sciences · 2023Review
- Music Therapy in Global Aphasia: A Case Report.Medicines (Basel, Switzerland) · 2023Article
- Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases.Frontiers in neuroscience · 2023Review
- Cognitive efficacy and neural mechanisms of music-based neurological rehabilitation for traumatic brain injury.Annals of the New York Academy of Sciences · 2022Review
- White matter dementia then… and now.Frontiers in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundTraumatic brain injury (TBI) is a common and devastating neurological condition, associated often with poor functional outcome and deficits in executive function. Due to the neuropathology of TBI, neuroimaging plays a crucial role in its assessment, and while diffusion MRI has been proposed as a sensitive biomarker, longitudinal studies evaluating treatment-related diffusion MRI changes are scarce. Recent evidence suggests that neurological music therapy can improve executive functions in patients with TBI and that these effects are underpinned by neuroplasticity changes in the brain. However, studies evaluating music therapy induced structural connectome changes in patients with TBI are lacking.
designSingle-blind crossover (AB/BA) randomized controlled trial (NCT01956136).
objectiveHere, we report secondary outcomes of the trial and set out to assess the effect of neurological music therapy on structural white matter connectome changes and their association with improved execute function in patients with TBI.
methodsUsing an AB/BA design, 25 patients with moderate or severe TBI were randomized to receive a 3-month neurological music therapy intervention either during the first (AB,
findingsCompared to the control group, the music therapy group increased quantitative anisotropy (QA) in the right dorsal pathways (arcuate fasciculus, superior longitudinal fasciculus) and in the corpus callosum and the right frontal aslant tract, thalamic radiation and corticostriatal tracts. The mean increased QA in this network of results correlated with improved executive function.
conclusionsThis study shows that music therapy can induce structural white matter neuroplasticity in the post-TBI brain that underpins improved executive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.