ArticleJournal of clinical medicine2022
Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Mortality Trends Involving Cardiac Arrest and Fluid, Electrolyte, and Acid-Base Disorders in U.S. Adults, 2004-2024.Journal of clinical medicine · 2026Article
- Diuretics in critically ill patients: a narrative review of their mechanisms and applications.British journal of anaesthesia · 2025Review
- Acid-Base Status in Critically Ill Patients: Physicochemical vs. Traditional Approach.Journal of clinical medicine · 2025Article
- Physico-chemical characterization of acid base disorders in patients with COVID-19: A cohort study.World journal of nephrology · 2024Article
- Insights into the baseline blood pH homeostasis at admission and the risk of in-hospital mortality in COVID-19 patients.Biomarkers in medicine · 2024Article
- Acid-base imbalance as a risk factor for mortality among COVID-19 hospitalized patients.Bioscience reports · 2023Article
- The association between acid-base status and clinical outcome in critically ill COVID-19 patients admitted to intensive care unit with an emphasis on high anion gap metabolic acidosis.Annals of clinical biochemistry · 2023Observational
- Inappropriate Ventilatory Homeostatic Responses in Hospitalized COVID-19 Patients.Frontiers in neurology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Our aim was to investigate the distribution of acid-base disorders in patients with COVID-19 ARDS using both the Henderson-Hasselbalch and Stewart's approach and to explore if hypoxemia can influence acid-base disorders. COVID-19 ARDS patients, within the first 48 h of the need for a non-invasive respiratory support, were retrospectively enrolled. Respiratory support was provided by helmet continuous positive airway pressure (CPAP) or by non-invasive ventilation. One hundred and four patients were enrolled, 84% treated with CPAP and 16% with non-invasive ventilation. Using the Henderson-Hasselbalch approach, 40% and 32% of patients presented respiratory and metabolic alkalosis, respectively; 13% did not present acid-base disorders. Using Stewart's approach, 43% and 33% had a respiratory and metabolic alkalosis, respectively; 12% of patients had a mixed disorder characterized by normal pH with a lower SID. The severe hypoxemic and moderate hypoxemic group presented similar frequencies of respiratory and metabolic alkalosis. The most frequent acid-base disorders were respiratory and metabolic alkalosis using both the Henderson-Hasselbalch and Stewart's approach. Stewart's approach detected mixed disorders with a normal pH probably generated by the combined effect of strong ions and weak acids. The impairment of oxygenation did not affect acid-base disorders.
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