ArticlePathogens (Basel, Switzerland)2022
Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China.
Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Cross-Species Transmission and Recombination Between Feline and Canine Coronaviruses in Jiangsu-Zhejiang Region in 2025.Veterinary sciences · 2026Article
- Development and Validation of a Triplex RT-qPCR Assay for Rapid Clinical Diagnosis and Serotyping of Feline Infectious Peritonitis Virus.International journal of molecular sciences · 2026Article
- Molecular and Clinical Screening of Selected Feline Viral Infections in Sulaymaniyah, Kurdistan Region, Iraq.Advances in virology · 2026Article
- High Prevalence of Multi-Viral Co-Infections and Low Rabies Seropositivity in Stray Cats of Shenzhen, China.Animals : an open access journal from MDPI · 2025Article
- Review
- From Challenge to Cure: A Look at Feline Infectious Peritonitis and Emerging Treatment Strategies and Breakthroughs.Veterinary sciences · 2025Review
- Rapid Clinical Resolution and Differential Diagnosis of a Neurological Case of Feline Infectious Peritonitis (FIP) Using GS-441524.Pathogens (Basel, Switzerland) · 2025Article
- Application of versatile reverse genetics system for feline coronavirus.Microbiology spectrum · 2025Article
- Feline Coronavirus in Northern Vietnam: Genetic Detection and Characterization Reveal Predominance of Type I Viruses.Viruses · 2025Article
- Circulation and Genetic Characterizations of Coronaviruses From Companion Animals in Chengdu, Southwest China: One-Year Postpandemic.Transboundary and emerging diseases · 2025Article
- Phylogenetic, clinical, pathological and epidemiological characterization of feline coronavirus infections in cats, in Istanbul.Frontiers in veterinary science · 2025Article
- A review of feline infectious peritonitis virus infection.Veterinary world · 2024Review
- Development and characterization of reverse genetics systems of feline infectious peritonitis virus for antiviral research.Veterinary research · 2024Article
- Genetic and Phylogenetic Analysis of Feline Coronavirus in Guangxi Province of China from 2021 to 2024.Veterinary sciences · 2024Article
- Myocarditis in an FIP-Diseased Cat with FCoV M1058L Mutation: Clinical and Pathological Changes.Animals : an open access journal from MDPI · 2024Article
- One-step triplex TaqMan quantitative reverse transcription polymerase chain reaction for the detection of feline coronavirus, feline panleukopenia virus, and feline leukemia virus.Veterinary world · 2024Article
- Prevalence and Risk Factors Associated with Feline Infectious Peritonitis (FIP) in Mainland China between 2008 and 2023: A Systematic Review and Meta-Analysis.Animals : an open access journal from MDPI · 2024Article
- Review
- An updated review of feline coronavirus: mind the two biotypes.Virus research · 2023Review
- Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Feline coronavirus (FCoV) infections present as one of two forms: a mild or symptom-less enteric infection (FEC) and a fatal systemic disease termed feline infectious peritonitis (FIP). The lack of epidemiology of FCoV in central China and the reason why different symptoms are caused by viruses of the same serotype have motivated this investigation. Clinical data of 81 suspected FIP cases, 116 diarrhea cases and 174 healthy cases were collected from veterinary hospitals using body cavity effusion or fecal samples. Risk factors, sequence comparison and phylogenetic studies were performed. The results indicated that FIPV was distinguished from FECV in the average hydrophobicity of amino acids among the cleavage sites of furin, as well as the mutation sites 23,531 and 23,537. FIPV included a higher minimal R-X-X-R recognition motif of furin (41.94%) than did FECV (9.1%). The serotype of FCoV was insignificantly correlated with FIP, and the clade 1 and clade 2 strains that appeared were unique to central China. Thus, it is hypothesized that this, along with the latent variables of an antigenic epitope at positions 1058 and 1060, as well as mutations at the S1/S2 sites, are important factors affecting FCoV transmission and pathogenicity.
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