ArticlePathogens (Basel, Switzerland)2022
The Prevalence of Onchocerciasis-Associated Epilepsy in Mundri West and East Counties, South Sudan: A Door-to-Door Survey.
Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Nodding Syndrome: The Need to Strengthen Epilepsy Care in Onchocerciasis-Endemic Areas and to Investigate the Pathogenesis of Onchocerciasis-Associated Epilepsy.The American journal of tropical medicine and hygiene · 2026Article
- Community-directed treatment with ivermectin in Maridi, South Sudan: Impact of an onchocerciasis awareness campaign and bi-annual treatment on therapeutic coverage.PLoS neglected tropical diseases · 2025Article
- A community-based vector control intervention "Slash and Clear" implemented in two onchocerciasis-endemic foci in South Sudan.PLoS neglected tropical diseases · 2025Article
- High epilepsy prevalence and excess mortality in onchocerciasis-endemic counties of South Sudan: A call for integrated interventions.PLoS neglected tropical diseases · 2025Article
- Accelerating onchocerciasis elimination in humanitarian settings: lessons from South Sudan.International health · 2025Article
- Epidemiology of epilepsy in Wulu County, an onchocerciasis-endemic area in South Sudan.Heliyon · 2024Article
- Active infection with Onchocerca volvulus and the linkage to epilepsy/nodding syndrome.PLoS neglected tropical diseases · 2024Article
- Impact of annual community-directed treatment with ivermectin on the incidence of epilepsy in Mvolo, a two-year prospective study.PLoS neglected tropical diseases · 2024Article
- Integration of onchocerciasis morbidity management and disability prevention services in the healthcare system in Tanzania: a call for action and recommendations.Tropical diseases, travel medicine and vaccines · 2024Article
- Mvolo County, an Onchocerciasis Endemic Area in Western Equatoria State, South Sudan: An Entomological Study to Prepare for a "Slash and Clear" Community-Based Vector Control Intervention.Research and reports in tropical medicine · 2024Article
- Response to: 'Methodological challenges for conducting case control studies to investigate the association between onchocerciasis and epilepsy including nodding syndrome'.Brain communications · 2024Article
- Methodological challenges for conducting case-control studies to investigate the association between onchocerciasis and epilepsy including nodding syndrome.Brain communications · 2024Article
- The Spectrum of Ocular Diseases in the Onchocerciasis-Endemic Focus of Raga in South Sudan.Research and reports in tropical medicine · 2024Article
- Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome.Brain communications · 2023Article
- Surveillance for Onchocerciasis-Associated Epilepsy and OV16 IgG4 Testing of Children 6-10 Years Old Should Be Used to Identify Areas Where Onchocerciasis Elimination Programs Need Strengthening.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors at 5 institutions in 7 countries.
Funding
Abstract
A two-phase survey of epilepsy was conducted in selected villages in Mundri West and East Counties (26 June-8 July, 2021), an onchocerciasis-endemic area in Western Equatoria State in South Sudan. In the first phase, households were visited by a trained research team to identify persons suspected to have epilepsy. In the second phase, persons suspected to have epilepsy were interviewed and examined by a clinician to confirm the diagnosis. A total of 364 households agreed to participate in the survey, amounting to 2588 individuals. The epilepsy screening questionnaire identified 91 (3.5%) persons with suspected epilepsy, of whom the diagnosis of epilepsy was confirmed by a clinician in 86 (94.5%). The overall prevalence of confirmed epilepsy was 3.3% (95% CI: 2.7-4.1%), and of nodding syndrome was 0.9% (95% CI: 0.6-1.4%). In 61 (16.8%) households there was at least one person with epilepsy. Only 1212 (46.9%) of 2583 people took ivermectin during the last distribution round in 2021. The annual epilepsy incidence was 77.3/100,000 (95% CI: 9.4-278.9/100,000) and the annual epilepsy mortality was 251.2/100,000 (95% CI: 133.8-428.7/100,000). In conclusion, a high prevalence and incidence of epilepsy was observed in villages in Mundri. Urgent action is needed to prevent children from developing onchocerciasis-associated epilepsy by strengthening the local onchocerciasis-elimination programme.
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