ReviewPathogens (Basel, Switzerland)2022
Diagnostic Advances in Childhood Tuberculosis-Improving Specimen Collection and Yield of Microbiological Diagnosis for Intrathoracic Tuberculosis.
Review in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Pediatric Tuberculosis Outside a Specialized TB Center: Clinical Presentation, Diagnostic Pathways, and Factors Associated with Microbiological Confirmation in a Romanian Tertiary Hospital.Microorganisms · 2026Article
- Uptake and feasibility of task-shifting of Xpert MTB/RIF Ultra testing from laboratory technicians to nurses to increase access and reduce time to results: a multicountry mixed method research.BMJ global health · 2026Article
- Diagnostic accuracy of the Fujifilm SILVAMP TB LAM II (FujiLAM II) assay for the diagnosis of childhood tuberculosis.BMC infectious diseases · 2026Article
- Tailoring Prevention and Control Strategies for Childhood Tuberculosis: From a Global Analysis of Burden Trends and Inequalities Across Three Age Groups (1990-2021) to Prevention and Control Strategies.Tropical medicine and infectious disease · 2026Article
- Pediatric pulmonary and extrapulmonary tuberculosis: immunological and diagnostic perspectives.BMC infectious diseases · 2026Article
- Drug-resistant tuberculosis and pulmonary co-infections in immunocompromised patients: from multi-omics to precision therapy.Frontiers in microbiology · 2026Review
- GeneXpert MTB/RIF Ultra in Pediatric Tuberculosis: How Disease Characteristics Modify Test Performances.Current pediatric reviews · 2026Article
- Disseminated tuberculosis with Poncet's disease mimicking childhood-onset systemic lupus erythematosus: a unique case report.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Sputum scarcity and respiratory sample availability among children with presumptive tuberculosis in high burden countries: a systematic review and meta-analysis.medRxiv : the preprint server for health sciences · 2025Article
- POCUS Examination of the Mediastinum in Children: A Simplified and Standardized Protocol for Pulmonary Tuberculosis.POCUS journal · 2025Article
- Using sputum and tongue swab specimens for in-home point-of-care targeted universal testing for tuberculosis of household contacts: an acceptability and feasibility analysis.BMJ global health · 2025Article
- Aflatoxin Exposure in Immunocompromised Patients: Current State and Future Perspectives.Toxins · 2025Review
- Commentary on "A case of necrotizing fasciitis secondary to cutaneous tuberculosis in a patient with systemic lupus erythematosus (SLE)".Annals of medicine and surgery (2012) · 2025Article
- Treatment decision algorithms for tuberculosis screening and diagnosis in children below 5 years hospitalised with severe acute malnutrition: a cost-effectiveness analysis.EClinicalMedicine · 2025Article
- A Comprehensive Review of the Diagnostics for Pediatric Tuberculosis Based on Assay Time, Ease of Operation, and Performance.Microorganisms · 2025Review
- What is New in the Diagnosis of Childhood Tuberculosis?Indian journal of pediatrics · 2024Review
- Article
- Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study.EClinicalMedicine · 2024Article
- Disseminated tuberculosis in a migrant child.BMJ case reports · 2024Article
- Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB.IJTLD open · 2024Article
Corrections and comments
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Authors and funding
12 authors at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is no microbiological gold standard for childhood tuberculosis (TB) diagnosis. The paucibacillary nature of the disease, challenges in sample collection in young children, and the limitations of currently available microbiological tests restrict microbiological confirmation of intrathoracic TB to the minority of children. Recent WHO guidelines recommend the use of novel rapid molecular assays as initial diagnostic tests for TB and endorse alternative sample collection methods for children. However, the uptake of these tools in high-endemic settings remains low. In this review, we appraise historic and new microbiological tests and sample collection techniques that can be used for the diagnosis of intrathoracic TB in children. We explore challenges and possible ways to improve diagnostic yield despite limitations, and identify research gaps to address in order to improve the microbiological diagnosis of intrathoracic TB in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.