Evidence map›Paper›PMID 35456056›Full record

ReviewPathogens (Basel, Switzerland)2022

Treatment of Rifampicin-Resistant Tuberculosis Disease and Infection in Children: Key Updates, Challenges and Opportunities.

Pauline Howell, Jay Achar, G Khai Lin Huang, Andrei Mariandyshev, H Simon Schaaf, Anthony J Garcia-Prats

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pauline HowellClinical HIV Research Unit, Department of Internal Medicine, Faculty of Medicine and Health Sciences, University of Witwatersrand, Sizwe Tropical Disease Hospital, 2 Modderfontein Road, Sandringham, Johannesburg 2131, South Africa.ORCID 0000-0002-5635-3134
Jay AcharDepartment of Global Public Health, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-2521-4422
G Khai Lin HuangTuberculosis Elimination and Implementation Science Working Group, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
Andrei MariandyshevDepartment of Phthisiopulmonary, Northern State Medical University, Troitsky Avenue 51, Arkhangel'sk 163000, Russia.ORCID 0000-0002-8485-5625
H Simon SchaafDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town 8000, South Africa.ORCID 0000-0001-5755-4133
Anthony J Garcia-PratsDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, P.O. Box 241, Cape Town 8000, South Africa.ORCID 0000-0002-9280-1950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children affected by rifampicin-resistant tuberculosis (RR-TB; TB resistant to at least rifampicin) are a neglected group. Each year an estimated 25,000-30,000 children develop RR-TB disease globally. Improving case detection and treatment initiation is a priority since RR-TB disease is underdiagnosed and undertreated. Untreated paediatric TB has particularly high morbidity and mortality. However, children receiving TB treatment, including for RR-TB, respond well. RR-TB treatment remains a challenge for children, their caregivers and TB programmes, requiring treatment regimens of up to 18 months in duration, often associated with severe and long-term adverse effects. Shorter, safer, effective child-friendly regimens for RR-TB are needed. Preventing progression to disease following

Indexed as

childrenmultidrug-resistantpaediatricspreventionrifampicin-resistanttreatmenttuberculosis

Identifiers

PMID35456056
PMCPMC9024964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.