Evidence map›Paper›PMID 35455967›Full record

ReviewCells2022

The Relevance of the Bacterial Microbiome, Archaeome and Mycobiome in Pediatric Asthma and Respiratory Disorders.

Carolin Baehren, Eleni Buedding, Aliyah Bellm, Frank Schult, Anton Pembaur, Stefan Wirth, Anja Ehrhardt, Friedrich Paulsen, Jan Postberg, Malik Aydin

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. The role of dog keeping in the home microbiota and its impact on children's health.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  3. Review
  4. First Report of the Pulmonary ParasiteAdvanced biomedical research · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Carolin BaehrenLaboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany.
Eleni BueddingLaboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany.
Aliyah BellmHelios Hospital Krefeld, Children's Hospital, Teaching Hospital of RTWH University Hospital Aachen, 47805 Krefeld, Germany.
Frank SchultCenter for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany.
Anton PembaurClinical Molecular Genetics and Epigenetics, Faculty of Health, Center for Biomedical Education & Research (ZBAF), Helios University Hospital Wuppertal, Witten/Herdecke University, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany.ORCID 0000-0002-7952-1532
Stefan WirthCenter for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany.
Anja EhrhardtInstitute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, Witten/Herdecke University, 58453 Witten, Germany.
Friedrich PaulsenInstitute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.ORCID 0000-0002-0527-0953
Jan PostbergClinical Molecular Genetics and Epigenetics, Faculty of Health, Center for Biomedical Education & Research (ZBAF), Helios University Hospital Wuppertal, Witten/Herdecke University, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany.ORCID 0000-0002-8562-3316
Malik AydinLaboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany.
Witten/Herdecke University · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHelios Klinikum Krefeld · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria, as well as eukaryotes, principally fungi, of the upper respiratory tract play key roles in the etiopathogenesis of respiratory diseases, whereas the potential role of archaea remains poorly understood. In this review, we discuss the contribution of all three domains of cellular life to human naso- and oropharyngeal microbiomes, i.e., bacterial microbiota, eukaryotes (mostly fungi), as well as the archaeome and their relation to respiratory and atopic disorders in infancy and adolescence. With this review, we aim to summarize state-of-the-art contributions to the field published in the last decade. In particular, we intend to build bridges between basic and clinical science.

Indexed as

AsthmaMicrobiotaMycobiomeArchaeaBacteriaChildEukaryotaFungiHumansallergyarchaeaasthmafungimicrobiomenasopharynxoropharynxrespiratory tract infections

Identifiers

PMID35455967
PMCPMC9024940
OpenAlexW4223446576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.