Evidence map›Paper›PMID 35455958›Full record

ArticleCells2022

Deletion of

Haixia Xu, Jiahua Guo, Wei Wu, Qiu Han, Yueru Huang, Yaling Wang, Cencen Li, Xiaofang Cheng, Pengpeng Zhang, Yongjie Xu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Heterogeneous Nuclear Ribonucleoprotein K (Animals : an open access journal from MDPI · 2026
    Article
  5. Article
  6. Review
  7. mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Article
  9. Article
  10. HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1.Reproductive biology and endocrinology : RB&E · 2025
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Haixia XuCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.ORCID 0000-0002-2732-0069
Jiahua GuoCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Wei WuCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Qiu HanCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Yueru HuangCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Yaling WangCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Cencen LiCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Xiaofang ChengCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Pengpeng ZhangCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Yongjie XuCollege of Life Science, Xinyang Normal University, Xinyang 464000, China.
Xinyang Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HnRNPK is a heterogeneous nuclear ribonucleoprotein (hnRNP) that has been firmly implicated in transcriptional and post-transcriptional regulation. However, the molecular mechanisms by which hnRNPK orchestrates transcriptional or post-transcriptional regulation are not well understood due to early embryonic lethality in homozygous knockout mice, especially in a tissue-specific context. Strikingly, in this study, we demonstrated that hnRNPK is strongly expressed in the mouse testis and mainly localizes to the nucleus in spermatogonia, spermatocytes, and round spermatids, suggesting an important role for hnRNPK in spermatogenesis. Using a male germ cell-specific hnRNPK-depleted mouse model, we found that it is critical for testicular development and male fertility. The initiation of meiosis of following spermatogenesis was not affected in

Indexed as

Heterogeneous-Nuclear Ribonucleoprotein KInfertility, MaleSpermatogenesisAnimalsGene DeletionMaleMeiosisMiceMice, KnockoutSpermatocytesHeterogeneous-Nuclear Ribonucleoprotein KHNRNPK protein, mousehnRNPKmeiosisspermatocytesspermatogenesistranscriptional regulation

Identifiers

PMID35455958
PMCPMC9028439
OpenAlexW4224241895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.