Evidence map›Paper›PMID 35455755›Full record

ArticleJournal of personalized medicine2022

Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary Study on Assessment of Tumor Aggressiveness and Response to Neoadjuvant Chemotherapy.

Miriam Dolciami, Silvia Capuani, Veronica Celli, Alessandra Maiuro, Angelina Pernazza, Innocenza Palaia, Violante Di Donato, Giusi Santangelo, Stefania Maria Rita Rizzo, Paolo Ricci and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  4. Toward diffusion MRI in the diagnosis and treatment of pancreatic cancer.Medical oncology (Northwood, London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Miriam DolciamiDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-8322-8435
Silvia CapuaniCNR Institute for Complex Systems (ISC), Physics Department, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-7863-1801
Veronica CelliDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2331-5235
Alessandra MaiuroPhysics Department, Sapienza University of Rome, 00161 Rome, Italy.
Angelina PernazzaDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-8608-2734
Innocenza PalaiaDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.
Violante Di DonatoDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Giusi SantangeloDepartment of Maternal and Child Health and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.
Stefania Maria Rita RizzoIstituto di Imaging della Svizzera Italiana (IIMSI), Ente Ospedaliero Cantonale (EOC), 6900 Lugano, Switzerland.ORCID 0000-0002-5151-0866
Paolo RicciDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5212-0678
Carlo Della RoccaDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.
Lucia ManganaroDepartment of Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-9037-9904
Policlinico Umberto I · ITEnte Ospedaliero Cantonale · CHInstitute for Complex Systems · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to determine whether quantitative parameters obtained from intravoxel incoherent motion (IVIM) model at baseline magnetic resonance imaging (MRI) correlate with histological parameters and response to neoadjuvant chemotherapy in patients with locally advanced cervical cancer (LACC).

methodsTwenty patients with biopsy-proven cervical cancer, staged as LACC on baseline MRI and addressed for neoadjuvant chemotherapy were enrolled. At treatment completion, tumor response was assessed with a follow-up MRI evaluated using the revised response evaluation criteria in solid tumors (RECIST; version 1.1), and patients were considered good responders (GR) if they had complete response or partial remission, and poor responders/non-responders (PR/NR) if they had stable or progressive disease. MRI protocol included conventional diffusion-weighted imaging (DWI; b = 0 and 1000 s/mm

resultsD showed significantly higher values in GR patients (

conclusionsD extracted from the IVIM model could represent a promising tool to identify tumor aggressiveness and predict response to therapy.

Indexed as

diffusion MRIintravoxel incoherent motionlocally advanced cervical cancertumor-infiltrating lymphocytes

Identifiers

PMID35455755
PMCPMC9027075
OpenAlexW4223958715

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.