Evidence map›Paper›PMID 35455695›Full record

ArticleJournal of personalized medicine2022

Decrease of Hyaluronidase Activity and Suppression of Mouse CD4+ T Lymphocyte Activation by Tomato Juice Saponin Esculeoside B, and Its Sapogenol Esculeogenin B.

Jian-Rong Zhou, Nozomi Kitahara, Honami Nakamura, Takuya Ono, Ryohei Karashima, Jun Fang, Toshihiro Nohara, Kazumi Yokomizo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Rapid Screening of Chemical Components inInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jian-Rong ZhouFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Nozomi KitaharaFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Honami NakamuraFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Takuya OnoFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Ryohei KarashimaFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Jun FangFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Toshihiro NoharaFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Kazumi YokomizoFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan.
Sojo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: A naturally occurring glycoside, esculeoside B (EsB), has been identified as a major component in juice or canned tomato. We reported how EsB ameliorated mice experimental atopic dermatitis by a decrease in serum IgE levels. However, the underlying immunologic molecular mechanisms are unknown. (2) Methods: The present study tested the effects of EsB on hyaluronidase activity and CD4+ T lymphocyte activation using concanavalin A (ConA)-blast mouse splenocyte primary culture. (3) Results: We found that EsB and its sapogenol esculeogenin B (Esg-B) decreased hyaluronidase activity by a modified Morgan-Elson method. We demonstrated that EsB/Esg-B dose-dependently suppressed T-lymphoproliferation using CFSE-labeled flow-cytometry and water-soluble tetrazolium (WST) assay. Using ELISA and q-PCR methods, EsB/Esg-B suppressed the cytokine secretion and mRNA expression of Th2-relevant IL-4 and Th1-relevant IFN-γ. Moreover, both EsB/Esg-B showed a reduction in IL-10 secretion, but only Esg-B decreased IL-2 secretion. (4) Conclusions: Our study is the first to demonstrate how EsB/Esg-B inhibit hyaluronidase activity and reduce CD4+ T-lymphocyte activation via a reduction in Th2-lymphocyte activity by modulation of Th2/Th1/Treg subunits differentiation.

Indexed as

CD4+ T lymphocyteesculeogenin B (Esg-B)esculeoside B (EsB)Th1Th2tomato juice/canned saponinTreg

Identifiers

PMID35455695
PMCPMC9025294
OpenAlexW4224319869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.