Evidence map›Paper›PMID 35455506›Full record

ArticleChildren (Basel, Switzerland)2022

Epigenome-Wide Analysis Reveals DNA Methylation Alteration in

Queletzu Aspra, Brenda Cabrera-Mendoza, Mirna Edith Morales-Marín, Carla Márquez, Carlos Chicalote, Ana Ballesteros, Miriam Aguilar, Xochitl Castro, Amalia Gómez-Cotero, Ana María Balboa-Verduzco and 7 more

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Queletzu AspraGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0003-2007-8641
Brenda Cabrera-MendozaPECEM, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico.ORCID 0000-0003-4729-9997
Mirna Edith Morales-MarínGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0001-5460-6284
Carla MárquezGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0002-6668-8763
Carlos ChicaloteCentro de Investigación y Atención en Salud Mental Kaelum Neurocenter S.C., Mexico City 53100, Mexico.
Ana BallesterosHospital Central PEMEX, Mexico City 02720, Mexico.
Miriam AguilarGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Xochitl CastroGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.
Amalia Gómez-CoteroCentro Interdisciplinario de Ciencias de la Salud (CICS-UST) Unidad Santo Tomás, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Ana María Balboa-VerduzcoCentro Interdisciplinario de Ciencias de la Salud (CICS-UST) Unidad Santo Tomás, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Lilia Albores-GalloHospital Psiquiátrico Infantil Juan N. Navarro, Secretaría de Salud, Mexico City 14080, Mexico.ORCID 0000-0001-5862-4404
Omar Nafate-LópezUnidad de Neuropsiquiatría, Hospital de Especialidades Pediátricas de Tuxtla Gutiérrez, Tuxtla Gutiérrez 29070, Mexico.
Carlos Alfonso Marcín-SalazarClinical Researcher at Clínica Mexicana de Autismo (CLIMA), Mexico City 03740, Mexico.
Patricia SánchezClinical Researcher at Clínica Mexicana de Autismo (CLIMA), Mexico City 03740, Mexico.
Nuria Lanzagorta-PiñolCarracci Medical Group, Mexico City 03740, Mexico.ORCID 0000-0001-6769-6813
Fernando Omar López-ArmentaCarracci Medical Group, Mexico City 03740, Mexico.
Humberto NicoliniGenomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico.ORCID 0000-0003-2494-0067
National Institute of Genomic Medicine · MXInstituto Politécnico Nacional · MXHospital de Especialidades · MXHospital Psiquiatrico Infantil Juan N Navarro · MXPemex (Mexico) · MXUniversidad Nacional Autónoma de México · MX

Funding

Consejo Nacional de Ciencia y Tecnología 433132Consejo Nacional de Ciencia y Tecnología Proyecto FOSISS 262115
6 · The paper itself

Abstract

Autism Spectrum Disorders (ASD) comprise a group of heterogeneous and complex neurodevelopmental disorders. Genetic and environmental factors contribute to ASD etiology. DNA methylation is particularly relevant for ASD due to its mediating role in the complex interaction between genotype and environment and has been implicated in ASD pathophysiology. The lack of diversity in DNA methylation studies in ASD individuals is remarkable. Since genetic and environmental factors are likely to vary across populations, the study of underrepresented populations is necessary to understand the molecular alterations involved in ASD and the risk factors underlying these changes. This study explored genome-wide differences in DNA methylation patterns in buccal epithelium cells between Mexican ASD patients (

Indexed as

AutismchildrenDNA methylationimprintingMexican

Identifiers

PMID35455506
PMCPMC9025761
OpenAlexW4221103833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.