Evidence map›Paper›PMID 35455477›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

A Theranostic Nanocomplex Combining with Magnetic Hyperthermia for Enhanced Accumulation and Efficacy of pH-Triggering Polymeric Cisplatin(IV) Prodrugs.

Yang Qu, Zhiqi Wang, Miao Sun, Tian Zhao, Xuanlei Zhu, Xiaoli Deng, Man Zhang, Ying Xu, Hongfei Liu

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yang QuCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Zhiqi WangCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Miao SunCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Tian ZhaoDepartment of Medical Imaging, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.
Xuanlei ZhuCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Xiaoli DengCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Man ZhangCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Ying XuCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Hongfei LiuCollege of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although polymeric platinum(IV) (Pt(IV)) prodrugs can reduce the side effects of cisplatin, the efficacy of the prodrug is still limited by its non-targeted distribution, poor penetration in deep tumor tissue, and low cytotoxicity in tumor cells. To improve the clinical potential of polymeric prodrug micelle, we synthesized amphiphilic polymeric Pt(IV) with high Pt content (22.5%), then developed a theranostic nanocomplex by integrating polymeric Pt(IV) with superparamagnetic Mn

Indexed as

magnetic hyperthermiamagnetic resonance imagingmagnetic targetingpH-triggering releasingpolymeric prodrugtheranostic nanocomplex

Identifiers

PMID35455477
PMCPMC9025582
OpenAlexW4224263397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.