Evidence map›Paper›PMID 35455454›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Alessia Mariano, Irene Bigioni, Roberto Mattioli, Antonella Di Sotto, Martina Leopizzi, Stefania Garzoli, Pier Francesco Mariani, Pietro Dalla Vedova, Sergio Ammendola, Anna Scotto d'Abusco

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Molecular Basis of Intron Retention inInternational journal of molecular sciences · 2025
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  8. The Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Review
  9. Aromatic Plants as Potential Resources to Combat Osteoarthritis.Combinatorial chemistry & high throughput screening · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alessia MarianoDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-9569-8952
Irene BigioniDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy.
Roberto MattioliDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-4452-9753
Antonella Di SottoDepartment of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7467-1689
Martina LeopizziDepartment of Medico-Surgical Sciences and Biotechnologies, Polo Pontino-Sapienza University, 04100 Latina, Italy.ORCID 0000-0002-9258-4191
Stefania GarzoliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8535-0533
Pier Francesco MarianiCasa di Cura Villa Stuart, 00135 Rome, Italy.
Pietro Dalla VedovaUOC di Ortopedia e Traumatologia, Ospedale Santa Scolastica di Cassino, ASL di Frosinone, 03043 Cassino, Italy.
Sergio AmmendolaAmbiotec S.A.S., 04012 Cisterna di Latina (LT), Italy.
Anna Scotto d'AbuscoDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy.ORCID 0000-0002-3323-6015
Sapienza University of Rome · ITUniversità degli studi di Cassino e del Lazio Meridionale · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endocannabinoid system is involved in the nociceptive and anti-inflammatory pathways, and a lowered expression of CB2 receptors has been associated with inflammatory conditions, such as osteoarthritis (OA). This suggests that CB2 modulators could be novel therapeutic tools to treat OA. In the present study, the involvement of

Indexed as

CB2devil’s clawendocannabinoid systemeugenolfibroblast-like synoviocytesharpagosideosteoarthritisvolatile compoundsα-humuleneβ-caryophyllene

Identifiers

PMID35455454
PMCPMC9026917
OpenAlexW4223416129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.