Evidence map›Paper›PMID 35455312›Full record

ArticleVaccines2022

An Association Study of HLA with the Kinetics of SARS-CoV-2 Spike Specific IgG Antibody Responses to BNT162b2 mRNA Vaccine.

Seik-Soon Khor, Yosuke Omae, Junko S Takeuchi, Ami Fukunaga, Shohei Yamamoto, Akihito Tanaka, Kouki Matsuda, Moto Kimura, Kenji Maeda, Gohzoh Ueda and 6 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Associations ofVaccines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Seik-Soon KhorGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.ORCID 0000-0002-6809-4731
Yosuke OmaeGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Junko S TakeuchiDepartment of Academic-Industrial Partnerships Promotion, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Ami FukunagaDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Shohei YamamotoDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Akihito TanakaDepartment of Laboratory Testing, Center Hospital of the National Center for the Global Health and Medicine, Tokyo 162-8655, Japan.
Kouki MatsudaDepartment of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Moto KimuraDepartment of Academic-Industrial Partnerships Promotion, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Kenji MaedaDepartment of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Gohzoh UedaDivision of Core Diagnostics, Abbott Japan LLC., Tokyo 105-7115, Japan.ORCID 0000-0002-2956-4171
Tetsuya MizoueDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Mugen UjiieDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.ORCID 0000-0001-8150-075X
Hiroaki MitsuyaDepartment of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Norio OhmagariDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Wataru SugiuraCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Katsushi TokunagaGenome Medical Science Project, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.ORCID 0000-0001-5501-0503
National Center for Global Health and Medicine · JPAbbott (Japan) · JP

Funding

Abbott (Japan) 20C050Japan Agency for Medical Research and Development JP20fk0108104Japan Agency for Medical Research and Development JP20kk0205012National Center for Global Health and Medicine 19K059National Center for Global Health and Medicine 2020-B-09National Center for Global Health and Medicine 20A2002DNational Center for Global Health and Medicine 21A006
6 · The paper itself

Abstract

BNT162b2, an mRNA-based SARS-CoV-2 vaccine (Pfizer-BioNTech, New York, NY, USA), is one of the most effective COVID-19 vaccines and has been approved by more than 130 countries worldwide. However, several studies have reported that the COVID-19 vaccine shows high interpersonal variability in terms of humoral and cellular responses, such as those with respect to SARS-CoV-2 spike protein immunoglobulin (Ig)G, IgA, IgM, neutralizing antibodies, and CD4

Indexed as

COVID-19HLAIgGJapanesePfizer-BioNTechSARS-CoV-2

Identifiers

PMID35455312
PMCPMC9029840
OpenAlexW4226086426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.