Evidence map›Paper›PMID 35454982›Full record

ArticleLife (Basel, Switzerland)2022

Proteomic Analysis of Endometrial Cancer Tissues from Patients with Type 2 Diabetes Mellitus.

Muhammad Mujammami, Mohamed Rafiullah, Assim A Alfadda, Khalid Akkour, Ibrahim O Alanazi, Afshan Masood, Mohthash Musambil, Hani Alhalal, Maria Arafah, Anas M Abdel Rahman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Muhammad MujammamiUniversity Diabetes Center, King Saud University Medical City, King Saud University, Riyadh 11461, Saudi Arabia.
Mohamed RafiullahStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0003-0583-3901
Assim A AlfaddaDepartment of Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0002-4792-5188
Khalid AkkourObstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0001-6302-5609
Ibrahim O AlanaziThe National Center for Biotechnology (NCB), Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.ORCID 0000-0002-8479-7875
Afshan MasoodProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0001-8082-9326
Mohthash MusambilProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0003-2402-9628
Hani AlhalalObstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Maria ArafahDepartment of Pathology, College of Medicine, King Saud University, King Saud University Medical City, Riyadh 11461, Saudi Arabia.ORCID 0000-0002-6847-5884
Anas M Abdel RahmanMetabolomics Section, Center for Genome Medicine, Department of Clinical Genomics, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riyadh 11211, Saudi Arabia.ORCID 0000-0002-9527-9424
Hicham BenabdelkamelProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.ORCID 0000-0001-9745-2959
King Saud University · SAKing Saud Medical City · SAAlfaisal University · SAKing Abdulaziz City for Science and Technology · SA

Funding

National Plan for Science, Technology and Innovation (MAARIFAH), King Abdulaziz City for Science and Technology, Saudi Arabia No. 08-MED513-02
6 · The paper itself

Abstract

Endometrial cancer (EC) is the most common form of gynecological cancer. Type 2 diabetes mellitus is associated with an increased risk of EC. Currently, no proteomic studies have investigated the role of diabetes in endometrial cancers from clinical samples. The present study aims to elucidate the molecular link between diabetes and EC using a proteomic approach. Endometrial tissue samples were obtained from age-matched patients (EC Diabetic and EC Non-Diabetic) during surgery. Untargeted proteomic analysis of the endometrial tissues was carried out using a two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF). A total of 53 proteins were identified, with a significant difference in abundance (analysis of variance (ANOVA) test,

Indexed as

2D-DIGEdiabetesendometrial cancerMALDI-TOFproteomicstissueuterus

Identifiers

PMID35454982
PMCPMC9030544
OpenAlexW4220851022

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.