ReviewCancers2022
A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk Prediction and Clinical Care.
Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Machine Learning Models for Predicting Pain, Fatigue, Depression, Anxiety, and Malnutrition in Cancer Patients: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Pooled it
- Diagnostic predictive models for cancer-related fatigue: current evidence and future directions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.Acta neurologica Belgica · 2025Pooled it
- Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Guideline
- A randomized trial on the feasibility of high-intensity interval training during chemotherapy in young breast cancer patients.Scientific reports · 2025Trial
- Time-restricted eating to address persistent cancer-related fatigue among cancer survivors: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Article
- Longitudinal Associations Between Inflammatory Biomarkers and Fatigue in Patients With Colorectal Cancer: A Multicenter Study.Cancer medicine · 2026Observational
- Self-reported physical fitness domains and perceptions of exercise and fatigue among childhood cancer survivors.JSAMS plus · 2026Article
- Effects of Sitting Baduanjin on Cancer-Related Fatigue in Patients With Advanced Cancer: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Article
- Evaluating non-linear thresholds and synergistic interactions in the comorbidity of preoperative insomnia and emergence agitation: a SHAP-based machine learning study.Frontiers in neurology · 2026Article
- Neurophysiological Markers of Cancer-Related Fatigue Derived from High-Density EEG.Brain topography · 2025Article
- Assessment of Active Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Infections and Patient Reported Fatigue in Ovarian Cancer Survivors.Cancer reports (Hoboken, N.J.) · 2025Article
- Biobehavioral correlates of multidimensional fatigue in men with prostate cancer: A secondary data analysis.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2025Observational
- Review
- Profoundly Depleted: Qualitative Study of Persistent Fatigue Following Hematopoietic Cell Transplant.Journal of pain and symptom management · 2025Article
- Breast Cancer Information Grand Round for Survivorship (BIG-S) prospective cohort.European journal of epidemiology · 2025Article
- Attention to cancer-related physical and mental fatigue: Breaking the vicious cycle.World journal of psychiatry · 2025Article
- Post-stroke fatigue - a multidimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue.The Journal of physiology · 2025Review
- The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer.Diseases (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
A major gap impeding development of new treatments for cancer-related fatigue is an inadequate understanding of the complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue. In this paper, we describe a new application of a comprehensive model for cancer-related fatigue: the predisposing, precipitating, and perpetuating (3P) factors model. This model framework outlined herein, which incorporates the emerging field of metabolomics, may help to frame a more in-depth analysis of the etiology of cancer-related fatigue as well as a broader and more personalized set of approaches to the clinical treatment of fatigue in oncology care. Included within this review paper is an in-depth description of the proposed biological mechanisms of cancer-related fatigue, as well as a presentation of the 3P model's application to this phenomenon. We conclude that a clinical focus on organization risk stratification and treatment around the 3P model may be warranted, and future research may benefit from expanding the 3P model to understand fatigue not only in oncology, but also across a variety of chronic conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.