ArticleCancers2022
Utilizing Three-Dimensional Culture Methods to Improve High-Throughput Drug Screening in Anaplastic Thyroid Carcinoma.
Kensey Bergdorf, Joshua A Bauer, David Westover, Courtney Phifer, Barbara Murphy, Darren R Tyson, Ethan Lee, Vivian L Weiss
Open access · goldAbstract read
In one paragraphArticle in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors at 2 institutions in 1 country.
Kensey BergdorfDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
David WestoverVanderbilt Institute of Chemical Biology-High-Throughput Screening Facility, Vanderbilt University, Nashville, TN 37232, USA.
Courtney PhiferDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Barbara MurphyVanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · US
Funding
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MMechanism of Wnt signal transductionR35GM122516 · NIGMS · VANDERBILT UNIVERSITY · PI ETHAN LEE · 2017 to 2026
$5.8MInhibition of the Wnt Receptor Complex by the Tumor Suppressor Adenomatous Polyposis ColiR01CA244188 · NCI · DARTMOUTH COLLEGE · PI AHMED, YASMATH, LEE, ETHAN · 2020 to 2024
$3.2MCancer Pharmacologist and HTS ScientistR50CA211206 · NCI · VANDERBILT UNIVERSITY · PI Joshua A. Bauer · 2016 to 2026
$1.8MIntegrated ImageXpress Micro Confocal High Content Screening SystemS10OD028719 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2021 to 2021
$799kResearch Specialist in Cancer Systems BiologyR50CA243783 · NCI · VANDERBILT UNIVERSITY · PI TYSON, DARREN R · 2019 to 2023
$781kNCI NIH HHS 1K08CA240901-01A1NCI NIH HHS 5F31C261060-02NCI NIH HHS K12 CA090625NCI NIH HHS K12CA090625NCI NIH HHS P30CA68485NCI NIH HHS R01 CA244188NCI NIH HHS R01CA244188NCI NIH HHS R50 CA211206NCI NIH HHS R50CA211206NCI NIH HHS R50 CA243783NCI NIH HHS R50CA243783NIGMS NIH HHS R35 GM122516NIGMS NIH HHS R35GM122516NIH HHS S10 OD028719NIH HHS T32GM007628-42
6 · The paper itselfAbstract
Anaplastic thyroid carcinoma (ATC) is the most aggressive endocrine neoplasm, with a median survival of just four to six months post-diagnosis. Even with surgical and chemotherapeutic interventions, the five-year survival rate is less than 5%. Although combination dabrafenib/trametinib therapy was recently approved for treatment of the ~25% of ATCs harboring
Indexed as
anaplastic thyroid carcinomahigh-throughput screeningspheroidstherapeutics
Identifiers
PMID35454763
PMCPMC9031362
OpenAlexW4224235049
What OpenQuestion holds
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LicenceCC BY
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