ArticleDiagnostics (Basel, Switzerland)2022
Pathological Evaluation of Rectal Cancer Specimens Using Micro-Computed Tomography.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Micro-Computed Tomography Based Whole Block Imaging of Asthma-Associated Airway Remodeling With Mycobacterium avium-Induced Cavity Formation: 3-Dimensional Nondestructive Analysis.Pathology international · 2026Article
- Micro-Computed Tomography Whole-Block Imaging Reveals Origin and Path of Rectal Cancer Tumor Deposits: A Pilot Study.Diagnostics (Basel, Switzerland) · 2024Article
- Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis.Histochemistry and cell biology · 2023Article
- X-ray phase-contrast 3D virtual histology characterises complex tissue architecture in colorectal cancer.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
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Authors and funding
14 authors.
Funding
Abstract
Whole-block imaging (WBI) using micro-computed tomography (micro-CT) allows the nondestructive reconstruction of a three-dimensional view of tissues, implying that WBI may be used for accurate pathological evaluation of patients with rectal cancer. HOWEVER, the clinical impact of this approach is unclear. We aimed to clarify the efficacy of WBI in the whole-mount specimens of locally advanced rectal cancer. A total of 237 whole-mount formalin-fixed paraffin-embedded blocks from 13 patients with rectal cancer who underwent surgical treatment were enrolled and scanned with micro-CT to generate three-dimensional images. WBI was evaluated following the conventional pathological review of the corresponding whole-slide imaging (WSI). WBI identified all tumor sites detected using WSI. Furthermore, WBI revealed one additional tumor site, which was not detected using WSI. Tumor resection margin was significantly closer to the soft-tissue edge when measured using WBI (7.7 mm vs. 6.6 mm, p < 0.01). Seventy-six percent of tumor deposits on WSI were changed according to the evidence of tumor interaction with the surrounding tissues confirmed using WBI. Furthermore, WBI revealed 25 additional lymph nodes, six of which were metastatic. The combination of conventional hematoxylin and eosin-stained imaging and WBI may contribute to an accurate pathological assessment.
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