Evidence map›Paper›PMID 35453668›Full record

ArticleBiomedicines2022

Expression of the Costimulatory Molecule B7-H4 in the Decidua and Placental Tissues in Patients with Placental Abruption.

Monika Bączkowska, Magdalena Maria Dutsch-Wicherek, Ewa Przytuła, Jan Faryna, Cezary Wojtyła, Mohamed Ali, Anna Knafel, Michał Ciebiera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Monika BączkowskaCentre of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland.
Magdalena Maria Dutsch-WicherekCentre of Postgraduate Medical Education, Department of Psychiatry, 01-809 Warsaw, Poland.
Ewa PrzytułaDepartment of Pathology, Bielański Hospital, 01-809 Warsaw, Poland.
Jan FarynaDepartment of Pathology, Bielański Hospital, 01-809 Warsaw, Poland.
Cezary WojtyłaInternational Prevention Research Institute-Collaborating Centre, Calisia University, 62-800 Kalisz, Poland.ORCID 0000-0002-1249-1893
Mohamed AliClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-9675-6691
Anna KnafelCentre of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland.
Michał CiebieraCentre of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland.ORCID 0000-0001-5780-5983
Postgraduate School of Molecular Medicine · PLAin Shams University · EG

Funding

Center of Postgraduate Medical Education, Warsaw, Poland 501-1-022-26-21
6 · The paper itself

Abstract

B7 homolog 4 protein (B7-H4), a member of the B7 family, is a immunomodulatory membrane protein. The aim of the study was to evaluate the expression of this protein in the decidua and placental tissues in case of placental abruption (PA) compared to cases of retained placental tissue (RPT) and controls. Tissue samples were obtained from 47 patients with PA, 60 patients with RPT, and 41 healthy controls. The samples were stained for B7-H4 expression, analyzed by an expert pathologist, and a semi-quantitative scale was applied. A statistical analysis revealed that the expression of B7-H4 was significantly higher in the decidua in PA samples compared to samples from patients with RPT (p-value < 0.001) and healthy controls (p-value < 0.001). The expression of B7-H4 in the placental chorionic villus was significantly higher in PA samples in relation to samples from healthy controls (p-value < 0.001) but not in relation to RPT samples (p-value = 0.0853). This finding suggests that B7-H4 might play an important role in mechanisms restoring reproductive tract homeostasis. Further research is necessary in regard to the role of B7-H4 in PA.

Indexed as

B7-H4cytotoxicitydeciduaimmunologymaternal–fetal interfaceplacental abruptionpregnancy

Identifiers

PMID35453668
PMCPMC9033103
OpenAlexW4223903582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.