Evidence map›Paper›PMID 35453646›Full record

ArticleBiomedicines2022

Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients.

Annika M A Berends, Mathieu S Bolhuis, Ilja M Nolte, Edward Buitenwerf, Thera P Links, Henri J L M Timmers, Richard A Feelders, Elisabeth M W Eekhoff, Eleonora P M Corssmit, Peter H Bisschop and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Annika M A BerendsDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Mathieu S BolhuisDepartment of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-5047-4077
Edward BuitenwerfDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Thera P LinksDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Henri J L M TimmersDepartment of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Richard A FeeldersDepartment of Endocrinology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Elisabeth M W EekhoffDepartment of Internal Medicine Section Endocrinology, Amsterdam University Medical Centers Location VUmc, 1117 HV Amsterdam, The Netherlands.ORCID 0000-0001-5399-676X
Eleonora P M CorssmitDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Peter H BisschopDepartment of Internal Medicine Section Endocrinology, Amsterdam University Medical Centers Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Harm R HaakDepartment of Internal Medicine, Máxima Medical Center, 5504 DB Eindhoven/Veldhoven, The Netherlands.ORCID 0000-0001-7385-9359
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Samira El BouazzaouiDepartment of Clinical Chemistry, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Bob WilffertDepartment of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Michiel N KerstensDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
University Medical Center Groningen · NLErasmus MC · NLAmsterdam University Medical Centers · NLRadboud University Nijmegen · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Presurgical treatment with an α-adrenergic receptor blocker is recommended to antagonize the catecholamine-induced α-adrenergic receptor mediated vasoconstriction in patients with pheochromocytoma or sympathetic paraganglioma (PPGL). There is, however, a considerable interindividual variation in the dose-response relationship regarding the magnitude of blood pressure reduction or the occurrence of side effects. We hypothesized that genetically determined differences in α-adrenergic receptor activity contribute to this variability in dose-response relationship. Methods: Thirty-one single-nucleotide polymorphisms (SNPs) of the α1A, α1B, α1D adrenoreceptor (ADRA1A, ADRA1B, ADRA1D) and α2A, α2B adrenoreceptor (ADRA2A, ADRA2B) genes were genotyped in a group of 116 participants of the PRESCRIPT study. Haplotypes were constructed after determining linkage disequilibrium blocks. Results: The ADRA1B SNP rs10515807 and the ADRA2A SNPs rs553668/rs521674 were associated with higher dosages of α-adrenergic receptor blocker (p < 0.05) and with a higher occurrence of side effects (rs10515807) (p = 0.005). Similar associations were found for haplotype block 6, which is predominantly defined by rs10515807. Conclusions: This study suggests that genetic variability of α-adrenergic receptor genes might be associated with the clinically observed variation in beneficial and adverse therapeutic drug responses to α-adrenergic receptor blockers. Further studies in larger cohorts are needed to confirm our observations.

Indexed as

adrenergic receptoralpha-adrenergic receptor blockerparagangliomapersonalized medicinepharmacogeneticspheochromocytomasingle nucleotide polymorphism

Identifiers

PMID35453646
PMCPMC9028965
OpenAlexW4224079072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.