Evidence map›Paper›PMID 35453610›Full record

ReviewBiomedicines2022

Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions.

Szidónia Farkas, Adrienn Szabó, Anita Emőke Hegyi, Bibiána Török, Csilla Lea Fazekas, Dávid Ernszt, Tamás Kovács, Dóra Zelena

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. HSPBiomedicines · 2025
    Article
  11. Article
  12. Casticin Inhibits Osteoclastogenesis via NF-κB/BCL-2 Signaling Pathway.Journal of microbiology and biotechnology · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Szidónia FarkasCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0003-4239-4936
Adrienn SzabóCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Anita Emőke HegyiCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Bibiána TörökCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Csilla Lea FazekasCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Dávid ErnsztCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Tamás KovácsCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
Dóra ZelenaCentre for Neuroscience, Szentágothai Research Center, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, Hungary.
University of Pecs · HUSemmelweis University · HU

Funding

National Research, Development and Innovation Office K141934, K138763 and K 120311Thematic Excellence Program 2021 Health Sub-programme of the Ministry for Innovation and Technology in Hungary TKP2021-EGA-16
6 · The paper itself

Abstract

Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and complications of traumatic injury. Previously, it was used mainly as a therapeutic option for influencing the menstrual cycle and treating menopausal symptoms. Unfortunately, hormone replacement therapy might be associated with detrimental side effects, such as increased risk of stroke and breast cancer, raising concerns about its safety. Thus, tissue-selective and non-classical estrogen analogues have become the focus of interest. Here, we review the current knowledge about estrogen effects in a broader sense, and the possibility of using selective estrogen-receptor modulators (SERMs), selective estrogen-receptor downregulators (SERDs), phytoestrogens, and activators of non-genomic estrogen-like signaling (ANGELS) molecules as treatment.

Indexed as

alternative therapiesANGELSestrogenmenopausenon-classical actionsosteoporosisphytoestrogensSERMstissue-selectivity

Identifiers

PMID35453610
PMCPMC9029610
OpenAlexW4224287165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.