Evidence map›Paper›PMID 35453451›Full record

ReviewAntioxidants (Basel, Switzerland)2022

Paraoxonase-1 Concentrations in Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis.

Maria Carmina Pau, Angelo Zinellu, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro G Fois, Arduino A Mangoni, Pietro Pirina

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Maria Carmina PauDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Angelo ZinelluDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8396-0968
Elisabetta ZinelluClinical and Interventional Pneumology, University Hospital Sassari (AOU), 07100 Sassari, Italy.
Gianfranco PintusDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3031-7733
Ciriaco CarruDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-6985-4907
Alessandro G FoisDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-5330-572X
Arduino A MangoniFlinders Medical Centre, Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0001-8699-1412
Pietro PirinaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-1457-8025
University of Sassari · ITFlinders University · AU

Funding

Ministry of Education, Universities and Research Programma Operativo Nazionale (PON) Ricerca e Innovazione 2014-2020", Asse I "Capitale Umano," Azione I.2 A.I.M, Attrazione e mobilita dei ricercatori, Linea 1 (Mobilità dei Ricerca-tori)University of Sassari Fondo di Ateneo per la Ricerca: annualità 2020
6 · The paper itself

Abstract

Obstructive sleep apnoea (OSA) is characterized by overproduction of reactive oxygen species and oxidative stress. The antioxidant enzyme paraoxonase-1 (PON-1) may be useful for monitoring the antioxidant defence systems and the effect of treatments in OSA patients. We investigated, by means of systematic review and meta-analysis, the serum concentrations of PON-1 in OSA patients and non-OSA controls. A literature search was conducted in PubMed, Web of Science, Scopus and Google Scholar databases, from the outset to November 2021, utilizing the terms: "paraoxonase" or "PON" or "paraoxonase-1" or "PON-1" and "obstructive sleep apnoea syndrome" or "OSAS" or "OSA". Eleven studies in 429 OSA patients and 258 non-OSA controls were involved in the meta-analysis. The pooled serum PON-1 concentrations were significantly lower in OSA (standardized mean difference (SMD) = -0.70, 95% CI -1.13 to -0.28;

Indexed as

obstructive sleep apnoeaoxidant–antioxidant imbalanceparaoxonase-1(PON-1)sleep disorder

Identifiers

PMID35453451
PMCPMC9028830
OpenAlexW4223632773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.