ArticleAntioxidants (Basel, Switzerland)2022
Valorization of Onion Waste by Obtaining Extracts Rich in Phenolic Compounds and Feasibility of Its Therapeutic Use on Colon Cancer.
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Anticancer Potential of Cucurbitaceae, Brassicaceae, Liliaceae and Chenopodiaceae: A Review of In Vitro Evidence.Molecules (Basel, Switzerland) · 2026Review
- Exploring the anti-inflammatory effects of genistein in an in vitro lipopolysaccharide-induced macrophage model.Scientific reports · 2026Article
- Valorization of Onion By-Products and Assessment of Their Biological Activities.Foods (Basel, Switzerland) · 2026Article
- Valorization of Onion-Processing Waste: Digestive Fate, Bioavailability, and Cellular Antioxidant Properties of Red and Yellow Peels Polyphenols.Antioxidants (Basel, Switzerland) · 2025Article
- Article
- Studies on unlocking the potential of onion waste extracts in edible coating for shelf-life extension of strawberry.Journal of food science and technology · 2025Article
- Antitumor Mechanisms ofLife (Basel, Switzerland) · 2024Review
- The amount of antioxidants in honey has a strong relationship with the plants selected by honey bees.Scientific reports · 2024Article
- Side Streams of Vegetable Processing and Its Bioactive Compounds Support Microbiota, Intestine Milieu, and Immune System.Molecules (Basel, Switzerland) · 2023Review
- Antioxidant and antiproliferative potentials of phenolic-rich extracts from biotransformed grape pomace in colorectal Cancer.BMC complementary medicine and therapies · 2023Article
- Article
- Anti-Inflammatory and Chondroprotective Effects Induced by Phenolic Compounds from Onion Waste Extracts in ATDC-5 Chondrogenic Cell Line.Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors.
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Abstract
In this study, the total phenolic content, the antioxidant and antiproliferative activities of onion waste extracts were characterized. Some phenolic compounds present in the extracts were also identified and quantified by HPLC-DAD. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The onion extract possessed a high amount of phenolic compounds (177 ± 9 mg/g extract) and had an effective antioxidant capacity measured by ABTS, FRAP and DPPH assays. Regarding the antiproliferative activity, the onion extracts produced cell cycle arrest in the S phase with p53 activation, intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation. Likewise, onion waste increased intracellular ROS with possible NF-kB activation causing a proteasome down regulation. In addition, the extracts protected the intestine against oxidative stress induced by H
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