Evidence map›Paper›PMID 35453412›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Investigating a Curcumin-Loaded PLGA-PEG-PLGA Thermo-Sensitive Hydrogel for the Prevention of Alzheimer's Disease.

Yi-Wen Lin, Chih-Hsiang Fang, Ching-Yun Yang, Ya-Jyun Liang, Feng-Huei Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  6. Smart hydrogels for in situ tissue drug delivery.Journal of biomedical science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yi-Wen LinInstitute of Biomedical Engineering, National Taiwan University, No.1, Sec. 1, Jen-Ai Road, Taipei 10617, Taiwan.
Chih-Hsiang FangTrauma and Emergency Center, China Medical University Hospital, No.2, Xueshi Rd., North Dist., Taichung 40454, Taiwan.
Ching-Yun YangInstitute of Biomedical Engineering, National Taiwan University, No.1, Sec. 1, Jen-Ai Road, Taipei 10617, Taiwan.
Ya-Jyun LiangInstitute of Biomedical Engineering, National Taiwan University, No.1, Sec. 1, Jen-Ai Road, Taipei 10617, Taiwan.
Feng-Huei LinInstitute of Biomedical Engineering, National Taiwan University, No.1, Sec. 1, Jen-Ai Road, Taipei 10617, Taiwan.ORCID 0000-0002-2994-6671
National Taiwan University · TWChina Medical University · TWNational Health Research Institutes · TW

Funding

Ministry of Science and Technology NSC 107-2221-E-002-070-MY3National Health Research Institutes 109-1901-01-19-07
6 · The paper itself

Abstract

In Alzheimer's disease (AD), the most common cause of dementia, patients generally forget to take pills or skip medication due to side effects, affecting the treatment efficacy. In this study, we combined a poly(lactic-co-glycolic acid), (PLGA)-poly(ethylene glycol), and (PEG)-PLGA thermo-sensitive hydrogel with curcumin (PGC) to deliver an intramuscular injection that could continuously release curcumin and maintain it at a constant level in blood to prevent AD development or progression. We evaluated the drug release profile and cytotoxicity of PGC and its effects on AD pathology through in vitro and in vivo studies and on cognitive function through an aluminum-chloride-induced AD rat model. In the in vitro study, PGC exhibited a lack of cytotoxicity, excellent anti-inflammatory and antioxidant properties, and microglial modulation. In the Morris water maze test, the PGC injection-administered AD rats presented well-focused searching behavior with the shortest swimming path and longest retention times in the quadrant where the platform was initially located. Furthermore, PGC reduced amyloid-beta aggregation and deposition and significantly increased hippocampal activity. This study demonstrated that intramuscular PGC injection can effectively prevent AD development or progression in rats without inducing toxicity; therefore, this strategy could help overcome the present challenges in AD management in humans.

Indexed as

Alzheimer’s diseaseamyloid betacurcuminpoly(ethylene glycol)poly(lactic-co-glycolic acid)

Identifiers

PMID35453412
PMCPMC9026862
OpenAlexW4224226528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.