Evidence map›Paper›PMID 35453365›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Supplementation with the Symbiotic Formulation Prodefen

Pablo Méndez-Albiñana, Ángel Martínez-González, Laura Camacho-Rodríguez, Álvaro Ferreira-Lazarte, Mar Villamiel, Raquel Rodrigues-Díez, Gloria Balfagón, Ana B García-Redondo, Mª Isabel Prieto-Nieto, Javier Blanco-Rivero

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Actinidin-Enriched Kiwifruit Concentrate (Kwd+International journal of molecular sciences · 2026
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  8. Antioxidant Foods and Cardiometabolic Health.Antioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Pablo Méndez-AlbiñanaDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Ángel Martínez-GonzálezDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Laura Camacho-RodríguezDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Álvaro Ferreira-LazarteGroup of Chemistry and Functionality of Carbohydrates and Derivatives, Food Science Research Institute (CIAL) (CSIC-UAM), 28049 Madrid, Spain.
Mar VillamielGroup of Chemistry and Functionality of Carbohydrates and Derivatives, Food Science Research Institute (CIAL) (CSIC-UAM), 28049 Madrid, Spain.
Raquel Rodrigues-DíezDepartment of Pharmacology and Therapeutics, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.ORCID 0000-0002-6348-1505
Gloria BalfagónDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Ana B García-RedondoDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.ORCID 0000-0002-5815-3320
Mª Isabel Prieto-NietoResearch Institute University Hospital la Paz (IdIPaz), 28029 Madrid, Spain.
Javier Blanco-RiveroDepartment of Physiology, School of Medicine, Universidad Autónoma de Madrid, 28029 Madrid, Spain.ORCID 0000-0001-7232-2314
Hospital La Paz Institute for Health Research · ESInstituto de Investigación en Ciencias de la Alimentación · ESUniversidad Autónoma de Madrid · ESHospital Universitario La Paz · ES

Funding

Centro de Investigación en Red en Enfermedades Cardiovasculares CB16/11/00286Comunidad de Madrid SI1-PJI-2019-00321Ministerio de Ciencia e Innovación (Spain) CDTI -Center for Industrial Technological Development- project PID 2020-FEDER FundsMinisterio de Ciencia e Innovación (Spain) PID2020-116498RB-I00,
6 · The paper itself

Abstract

In recent years, gut dysbiosis has been related to some peripheral vascular alterations linked to hypertension. In this work, we explore whether gut dysbiosis is related to vascular innervation dysfunction and altered nitric oxide (NO) production in the superior mesenteric artery, one of the main vascular beds involved in peripheral vascular resistance. For this purpose, we used spontaneously hypertensive rats, either treated or not with the commercial synbiotic formulation Prodefen

Indexed as

hypertensionneuronal nitric oxideNrf2oxidative stressperivascular mesenteric innervationPI3K-AKTprotein kinase Aprotein kinase Csynbiotic

Identifiers

PMID35453365
PMCPMC9029967
OpenAlexW4220975043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.