ReviewAntibiotics (Basel, Switzerland)2022
Antibiotic Therapy for Prosthetic Joint Infections: An Overview.
Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Metal-artefact-reduction MRI for diagnosing periprosthetic joint infection: a systematic review and meta-analysis.Skeletal radiology · 2026Pooled it
- The effect of extended postoperative oral antibiotic prophylaxis on the reinfection risk following two-stage exchange arthroplasty for hip and knee periprosthetic joint infection: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- Comparative evaluation of treatment strategies for femoral metastases: endoprosthesis reconstruction versus intramedullary nailing.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Pooled it
- Corynebacterium periprosthetic joint infection: a systematic review of 52 cases at 2.5 years follow-up.Archives of orthopaedic and trauma surgery · 2023Pooled it
- [Antimicrobial therapy of periprosthetic joint infection : Summary of AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- From Trends to Insights: Management of Periprosthetic Joint Infections in the Past Decade in The Netherlands.Microorganisms · 2026Article
- Visual Case Report of a Prosthetic Joint Infection and Chronic Dehiscence following a Total Knee Arthroplasty.Journal of education & teaching in emergency medicine · 2026Article
- Clinical Outcomes and Safety Profile of Vancomycin in Outpatient Parenteral Antimicrobial Therapy Services: A Systematic Review.Antibiotics (Basel, Switzerland) · 2026Review
- Modulating Micrococcal Nuclease-Triggered Antibiotic Releases for One-Stage Revisions ofACS infectious diseases · 2026Article
- Short Against Long Antibiotic Therapy for Infected Orthopaedic Sites-2nd Interim Analysis of the SALATIO Trials.Journal of clinical medicine · 2026Article
- Cefepime/enmetazobactam for Gram-negative periprosthetic joint infections? A randomized porcine study on target tissue pharmacokinetics.The Journal of antimicrobial chemotherapy · 2026Article
- Enzymes-enhanced antibiotic therapy reduces biofilms to undetectable levels in an implant-associated infection model.NPJ biofilms and microbiomes · 2026Article
- The Application of artificial intelligence in periprosthetic joint infection.Journal of advanced research · 2026Review
- High failure rate inJournal of bone and joint infection · 2026Article
- Article
- Old germs, novel approaches - A systematic review on pathogen distribution and therapeutic intervention strategies in periprosthetic joint infections.European journal of microbiology & immunology · 2025Review
- Extensive Femoral Bone Loss Following Two-Stage Periprosthetic Joint Infection Treatment: Persistent Challenges in Proximal Femoral Replacement.Arthroplasty today · 2025Article
- The Role of Unexpected Infection in Acetabular Erosion After Hip Hemiarthroplasty.Medicina (Kaunas, Lithuania) · 2025Observational
- Treatment Duration in Bacterial Prosthetic Joint Infections: A Narrative Review of Current Evidence.Antibiotics (Basel, Switzerland) · 2025Review
- Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks.Clinical and experimental dental research · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prosthetic joint infection (PJI) is a severe complication after arthroplasty. Its management combines surgical intervention, whose type depends on the clinical situation, and prolonged high-dose antibiotics adapted to the responsible microorganism(s) and the patient. Antibiotics are only one part of the therapeutic regimen and are closely related to the surgical strategy. Their efficacy depends to a large extent on the choice and quality of the surgical procedure, and the quality of the microbiological diagnosis. Although guidelines have been published, many aspects of antibiotic therapy remain poorly established. Choosing the optimal agent(s) is one aspect, with others being optimization of drugs' pharmacokinetic/pharmacodynamic parameters, the choice of administration route, use of monotherapy or combination regimens, therapeutic drug-monitoring and patient education to improve compliance and tolerance. Herein, we address PJI management based on recent literature data, guidelines and the experience of our referral center for complex bone-and-joint infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.