Evidence map›Paper›PMID 35453177›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity.

Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H Ruiz, Xiang Weng, Michael D Cameron, Yanwen Duan, Yong Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Youchao DengXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Yuling LiXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Zhongqing WenXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Claudia H RuizDepartments of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.
Xiang WengXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Michael D CameronDepartments of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.
Yanwen DuanXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Yong HuangXiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.ORCID 0000-0002-3163-1716

Funding

Hunan Provincial Natural Science Foundation of China 2021JJ30791National Natural Science Foundation of China 82173688the Chinese Ministry of Education 111 Project BP0820034the Fundamental Research Funds for the Central Universities of Central South University 2018zzts240the science and technology innovation Program of Hunan Province 2021RC4067
6 · The paper itself

Abstract

Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against

Indexed as

antibioticC–C cross-coupling reactionsFabBFabFplatensimycinStaphylococcus aureus

Identifiers

PMID35453177
PMCPMC9027111

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.