Evidence map›Paper›PMID 35453059›Full record

ArticleRespiratory medicine2022

Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study.

Caroline Espersen, Elke Platz, Alia Saed Alhakak, Morten Sengeløv, Jakob Øystein Simonsen, Niklas Dyrby Johansen, Filip Søskov Davidovski, Jacob Christensen, Henning Bundgaard, Christian Hassager and 16 more

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04377035 (The ECHOVID-19 Study - A Prospective Cohort Study Investigating the Acute Effect of COVID-19 on the Heart and Lung by Ultrasound), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04377035 completednot on this map

The ECHOVID-19 Study - A Prospective Cohort Study Investigating the Acute Effect of COVID-19 on the Heart and Lung by Ultrasound

TypeobservationalSponsorUniversity Hospital, Gentofte, CopenhagenRan2020 to 2021Enrolled305ConditionsCOVID-19
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Usefulness of CJournal of clinical medicine · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 2 countries.

Caroline EspersenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: caroline.espersen@regionh.dk.
Elke PlatzCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Alia Saed AlhakakDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Morten SengeløvDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jakob Øystein SimonsenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Niklas Dyrby JohansenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Filip Søskov DavidovskiDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jacob ChristensenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Henning BundgaardDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Christian HassagerDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Reza JabbariDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jørn CarlsenDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ole KirkDepartment of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Matias Greve LindholmDepartment of Cardiology, Zealand University Hospital Roskilde, Roskilde, Denmark.
Ole Peter KristiansenDepartment of Cardiology, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Olav Wendelboe NielsenDepartment of Cardiology, Bispebjerg & Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus Nielsen JeschkeDepartment of Anesthesiology and Intensive Care, Hospital Sønderjylland, Aabenraa, Denmark.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Amager & Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Pradeesh SivapalanDepartment of Medicine, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Kasper IversenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jens Ulrik Stæhr JensenDepartment of Medicine, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morten SchouDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Søren Helbo SkaarupDepartment of Respiratory Medicine, Aarhus University Hospital, University of Aarhus, Denmark.
Mats Christian Højbjerg LassenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Kristoffer Grundtvig SkaarupDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Tor Biering-SørensenDepartment of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKAarhus University Hospital · DKBrigham and Women's Hospital · USSygehus Sønderjylland · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung ultrasound (LUS) is a useful tool for diagnosis and monitoring in patients with active COVID-19-infection. However, less is known about the changes in LUS findings after a hospitalization for COVID-19.

methodsIn a prospective, longitudinal study in patients with COVID-19 enrolled from non-ICU hospital units, adult patients underwent 8-zone LUS and blood sampling both during the hospitalization and 2-3 months after discharge. LUS images were analyzed blinded to clinical variables and outcomes.

resultsA total of 71 patients with interpretable LUS at baseline and follow up (mean age 64 years, 61% male, 24% with acute respiratory distress syndrome (ARDS)) were included. The follow-up LUS was performed a median of 72 days after the initial LUS performed during hospitalization. At baseline, 87% had pathologic LUS findings in ≥1 zone (e.g. ≥3 B-lines, confluent B-lines or subpleural or lobar consolidation), whereas 30% had pathologic findings at follow-up (p < 0.001). The total number of B-lines and LUS score decreased significantly from hospitalization to follow-up (median 17 vs. 4, p < 0.001 and 4 vs. 0, p < 0.001, respectively). On the follow-up LUS, 28% of all patients had ≥3 B-lines in ≥1 zone, whereas in those with ARDS during the baseline hospitalization (n = 17), 47% had ≥3 B-lines in ≥1 zone.

conclusionLUS findings improved significantly from hospitalization to follow-up 2-3 months after discharge in COVID-19 survivors. However, persistent B-lines were frequent at follow-up, especially among those who initially had ARDS. LUS seems to be a promising method to monitor COVID-19 lung changes over time. CLINICALTRIALS: GOV ID: NCT04377035.

Indexed as

COVID-19Respiratory Distress SyndromeAdultCohort StudiesFemaleHospitalizationHumansLongitudinal StudiesLungMaleMiddle AgedProspective StudiesUltrasonographyCOVID-19Longitudinal follow-upLung ultrasound

Identifiers

PMID35453059
PMCPMC8976570
OpenAlexW4224309394

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.